NDLI: Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan

Content Provider	Springer Nature Link
Author	Ikeda, Masayuki Moriguchi, Jiro Sakuragi, Soko Ohashi, Fumiko
Copyright Year	2012
Abstract	Whereas information has been accumulating on the association of anemia and other diseases with cadmium (Cd) burden, histories of past diseases of the examinees are often not taken in account when the results of health examination are evaluated for cadmium exposure-related health effects on general populations. The present study was initiated to examine the possible association of previous diseases with Cd exposure parameters, taking advantage of compiled data on adult women.Data were cited from previous publications of this research group on Cd, α1-microglobulin (α1-MG), β2-microglobulin (β2-MG), N-acetyl-β-d-glucosaminidase (NAG) and urine density makers (i.e., creatinine and specific gravity) in the urine of more than 17,000 adult women in non-polluted areas in Japan. Information on previous disease history together with age and smoking habits was obtained by self-administered questionnaires, and 13,031 never-smoking women were selected for the present analyses. To compare the cases with disease history, control cases were randomly selected after stratification by 5 years of age at a ratio of one case to three controls from those with no disease history; summation for all age strata made up the control groups for the disease group in concern. The random sampling to set up control groups was repeated three times in total. The difference between the disease group and control groups was considered valid in cases the difference was statistically significant (p ≦ 0.05), in all three cases after correction (or non-correction) for urine density, and the same results were obtained when compared with the three different control groups.In the anemia group, Cd–U was higher over corresponding three control groups, although none of α1-MG–U, β2-MG–U or NAG–U showed significant changes. In the diabetes mellitus group, NAG–U was higher than in the controls, but such differences were not observed in Cd–U or β2-MG–U. The elevation in α1-MG–U was not reproducible. In the case of the hypertension group, the elevations in Cd–U, α1-MG–U, and β2-MG–U were observed, but changes in NAG–U could not be confirmed. In the analysis of dose–response relationship, the diabetes mellitus group showed increases in the slope for β2-MG–U and in the intercept for NAG–U. No changes in dose–response relationship were observed in other disease groups as compared with the corresponding control groups.Care should be taken in evaluating Cd-related health examination results for those with history of diseases such as hypertension, anemia and diabetes mellitus in particular.
Starting Page	343
Ending Page	355
Page Count	13
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	86
Issue Number	3
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-04-13
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cadmium in urine Japanese women Never-smoking Non-polluted areas Past diseases Tubular dysfunction markers in urine Environmental Health Rehabilitation Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Relation of child birth and breast-feeding burden with cadmium and tubular dysfunction marker levels in urine of adult women in non-polluted areas in Japan

Effects of aging on cadmium and tubular dysfunction markers in urine from adult women in non-polluted areas

Bi-linear dose–response relationship in general populations with low-level cadmium exposures in non-polluted areas in Japan

Lead Levels in Urine of Never-Smoking Adult Women in Non-Polluted Areas in Japan, with References to Cadmium Levels in Urine

Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

Analysis for threshold levels of cadmium in urine that induce tubular dysfunction among women in non-polluted areas in Japan

Cadmium and tubular dysfunction marker levels in urine of residents in non-polluted areas with natural abundance of cadmium in Japan

Changes in tubular dysfunction marker levels in parallel with the levels of copper, rather than cadmium, in urine of middle-aged women in non-polluted areas

Smoking-induced increase in urinary cadmium levels among Japanese women

Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan

Similar Documents

Relation of child birth and breast-feeding burden with cadmium and tubular dysfunction marker levels in urine of adult women in non-polluted areas in Japan

Effects of aging on cadmium and tubular dysfunction markers in urine from adult women in non-polluted areas

Bi-linear dose–response relationship in general populations with low-level cadmium exposures in non-polluted areas in Japan

Lead Levels in Urine of Never-Smoking Adult Women in Non-Polluted Areas in Japan, with References to Cadmium Levels in Urine

Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

Analysis for threshold levels of cadmium in urine that induce tubular dysfunction among women in non-polluted areas in Japan

Cadmium and tubular dysfunction marker levels in urine of residents in non-polluted areas with natural abundance of cadmium in Japan

Changes in tubular dysfunction marker levels in parallel with the levels of copper, rather than cadmium, in urine of middle-aged women in non-polluted areas

Smoking-induced increase in urinary cadmium levels among Japanese women

Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan