NDLI: Cytological damage of nasal epithelium associated with decreased glutathione peroxidase in residents from a heavily polluted city

Content Provider	Springer Nature Link
Author	Hernández Escobar, S. A. Ávila Casado, M. C. Soto Abraham, V. López Escudero, O. L. Soto, M. E. Vega Bravo, M. L. Goes, T. Fortoul Reyes Maldonado, Elba
Copyright Year	2008
Abstract	To evaluate the cytological damage and glutathione peroxidase (GPX) content in the nasal epithelium of residents of Southwest Metropolitan Mexico City (SWMMC) along 1 year of ozone and PM10 exposure.Four nasal scrapings were obtained in 20 volunteers from a control low polluted city and SWMMC permanent residents (n = 20) during 1 year. The scrapings were obtained in September and December 2004, and February and May 2005. One part of the scraping was stained by hematoxylin–eosin technique for cytological evaluation and a second part was stained by immunocytochemistry method to evaluate GPX concentration by morphometry.Control subjects: in total, 30% had no cytological alterations and 70% showed only mild or moderate inflammation in four nasal scrapings. All SWMMC residents showed moderate to severe inflammatory processes in some scrapings. Additionally, dysplasia was found once (in 2 cases) or more than on scraping in five cases (25%). GPX concentration in the control group remained highest in median values throughout the study. SWMMC residents with the highest median values of GPX content were found in the May and September scrapings, and the lowest median values were found in December and February when Ozone and PM10 levels are increased (P ≤ 0.05). A lower GPX content was found as the cytological damage increased (P ≤ 0.001).Cytological evaluation of nasal epithelium and GPX immunodetection are satisfactory methods to evaluate the earliest damage produced by atmospheric pollution in heavily contaminated cities.
Starting Page	603
Ending Page	612
Page Count	10
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	82
Issue Number	5
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-11-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Glutathione peroxidase (GPX) Immunocytochemistry Nasal epithelium Environmental pollution Dysplasia Inflammation Environmental Health Rehabilitation Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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