NDLI: Priming of cytokine release and increased levels of bactericidal permeability-increasing protein in the blood of animal facility workers

Content Provider	Springer Nature Link
Author	Borm, P. J. A. van Hartingsveld, B. Schins, P. F. R. Alfaro More, E. Cruz Rico, G. Rosas Perez, I. Osornio Vargas, A. R.
Copyright Year	1999
Abstract	Objective: To investigate cellular immune responses in laboratory animal workers who are exposed to high levels of animal allergens but also to other biologically active substances containing lipopolysaccharides (LPS), i.e., endotoxins. Methods: A survey among 20 animal facility workers and 20 matched (gender, smoking) controls was conducted using exposure measurements (endotoxin, colony-forming units of bacteria and fungi) and a questionnaire on respiratory symptoms. Blood samples were taken to determine the ex vivo whole-blood release of tumor necrosis factor-alpha (TNF) and interleukin-8 (IL-8) as well as plasma levels of LPS-binding protein (LBP), bactericidal permeability-increasing protein (BPI), the 75-kDa soluble TNF receptor (sTNFR75), and total/specific IgE. Results: Although exposure to endotoxin was low (range 0.05–2.8 ng/m3), a significant (P < 0.05) increase in plasma BPI (4-fold) and srTNF75 (1.2-fold) was found, suggesting a response to inhalation of LPS. Also, the capacity of blood leukocytes to release TNF and IL-8 in response to ex vivo exposure to workplace dust was increased. Data were not confounded by specific allergies, levels of IgE, smoking, or respiratory symptoms. Conclusions: A profound effect on the cellular immune response was seen in animal workers with low endotoxin exposure and a high antigenic load. It remains to be determined which other biologically active substance(s) are involved in this effect.
Starting Page	323
Ending Page	329
Page Count	7
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	72
Issue Number	5
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-08-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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