NDLI: The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells

Content Provider	Springer Nature Link
Author	Müller, Dieter Davidoff, Michail S. Bargheer, Oliver Paust, Hans J. Pusch, Wolfgang Koeva, Yvetta Ježek, Davor Holstein, Adolf F. Middendorff, Ralf
Copyright Year	2006
Abstract	Previous studies have demonstrated local functions for neurotrophins in the developing and mature testis of rodents. To examine whether these signaling molecules are present and also potentially active in the human testis, we characterized immunohistochemically the expression and cellular localization of the known neurotrophins and their receptors during prenatal testicular development as well as in the adult human testis. Results obtained revealed the presence of nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 and 4, as well as neurotrophin receptors p75NTR, TrkA, TrkB, and TrkC during testis morphogenesis. These proteins were also detectable in the adult human testis, and their local expression could be confirmed largely by immunoblot and RT-PCR analyses. Remarkably, the Leydig cells were found to represent the predominant neurotrophin/receptor expression sites within both fetal and adult human testes. Functional assays performed with a mouse tumor Leydig cell line revealed that NGF exposure increases cellular steroid production, indicating a role in differentiation processes. These findings support previously-recognized neuronal characteristics of Leydig cells, provide additional evidence for potential roles of neurotrophins during testis morphogenesis and in the mature testis, and demonstrate for the first time a neurotrophin-induced functional activity in Leydig cells.
Starting Page	199
Ending Page	211
Page Count	13
File Format	PDF
ISSN	09486143
Journal	Histochemistry and Cell Biology
Volume Number	126
Issue Number	2
e-ISSN	1432119X
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-02-07
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Differentiation Human testis Leydig cells MA-10 cells NGF Neurotrophins Anatomy Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Molecular Biology Medical Laboratory Technology

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