NDLI: Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution

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Histochemistry and Cell Biology : Volume 124, Issue 1, July 2005

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Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution

Content Provider	Springer Nature Link
Author	Ortiz Delgado, J. B. Simes, D. C. Gavaia, P. Sarasquete, C. Cancela, M. L.
Copyright Year	2005
Abstract	In this study, the tissue distribution and accumulation of osteocalcin or bone Gla protein (BGP) and matrix Gla protein (MGP) were determined during tooth development in a teleost fish, Argyrosomus regius. In this species, the presence of BGP and MGP mRNA in teeth was revealed by in situ hybridization. mRNA for BGP was detected in the odontoblasts as well as in its cytoplasmic processes emerging through dentinal tubules, while mRNA for MGP was expressed in the enamel portion within the apical portion of the elongated cell bodies of enameloblasts, adjacent to the root of the teeth as well as in cells within the pulpal space. Immunolocalization of BGP and MGP demonstrated that these proteins accumulate mainly in the mineralized dentin or in enameloblastic processes, confirming in situ hybridization results. In this study, we examined for the first time the localization of both BGP and MGP gene expression and protein accumulation within the different regions of the vertebrate tooth. We clearly demonstrated that although the overall pattern of BGP and MGP gene expression and protein accumulation in A. regius teeth was in general agreement to what is known for other vertebrates such as rats or rodents, our study provided novel information and highlighted some species-differences between fish and higher vertebrates.
Starting Page	123
Ending Page	130
Page Count	8
File Format	PDF
ISSN	09486143
Journal	Histochemistry and Cell Biology
Volume Number	124
Issue Number	2
e-ISSN	1432119X
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-07-09
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Osteocalcin BGP Matrix Gla protein MGP Teleost fish Immunohistochemistry Teeth In situ hybridization Medicine/Public Health Anatomy
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Molecular Biology Medical Laboratory Technology

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