NDLI: Cell-type specific proximity of centromeric domains of one homologue each of chromosomes 2 and 11 in nuclei of cerebellar Purkinje neurons

Content Provider	Springer Nature Link
Author	Vadakkan, Kunjumon I. Li, Baoxiang De Boni, Umberto
Copyright Year	2006
Abstract	In Purkinje neurons of the mouse cerebellum, the centromeres of several chromosomes are placed in close proximity to form a distinct pattern of clusters and exhibit reproducible spatial redistributions during development. In granule neurons, an adjacent cell type in the cerebellum, the pattern, size, and number of centromeric aggregations are different from those of Purkinje neurons. The present work was undertaken to test the hypothesis that the same chromosomes form part of one aggregate in a cell-type-specific manner. Fluorescence in situ hybridization (FISH) with chromosome-specific paracentromeric probes was used to identify centromeric regions of individual chromosomes in cerebellar Purkinje and granule neurons of the adult mouse. When pairs of centromeric probes were used in two-color FISH, one homologue each of chromosomes 2 and 11 were routinely found close to each other in Purkinje neurons but not in granule neurons. This finding of specific proximity was limited to the pair 2 and 11, out of the ten chromosome pairs that were randomly selected and studied. Our results indicate that, in adult Purkinje neurons, a cell-type-specific spatial proximity is present between centromeric domains of one homologue each of chromosomes 2 and 11.
Starting Page	395
Ending Page	402
Page Count	8
File Format	PDF
ISSN	00095915
Journal	Chromosoma
Volume Number	115
Issue Number	5
e-ISSN	14320886
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-06-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Animal Genetics and Genomics Eukaryotic Microbiology Developmental Biology Cell Biology Biochemistry Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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