NDLI: The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze

Content Provider	Springer Nature Link
Author	Staněk, David Neugebauer, Karla M.
Copyright Year	2006
Abstract	Spliceosomal small nuclear ribonucleoprotein particles (snRNPs) are essential pre-mRNA splicing factors that consist of small nuclear RNAs (snRNAs) complexed with specific sets of proteins. A considerable body of evidence has established that snRNP assembly is accomplished after snRNA synthesis in the nucleus through a series of steps involving cytoplasmic and nuclear phases. Recent work indicates that snRNPs transiently localize to the Cajal body (CB), a nonmembrane-bound inclusion present in the nuclei of most cells, for the final steps in snRNP maturation, including snRNA base modification, U4/U6 snRNA annealing, and snRNA-protein assembly. Here, we review these findings that suggest a crucial role for CBs in the spliceosome cycle in which production of new snRNPs—and perhaps regenerated snRNPs after splicing—is promoted by the concentration of substrates in this previously mysterious subnuclear organelle. These insights allow us to speculate on the role of nuclear bodies in regulating the dynamics of RNP assembly to maintain a functional pool of factors available for key steps in gene expression.
Starting Page	343
Ending Page	354
Page Count	12
File Format	PDF
ISSN	00095915
Journal	Chromosoma
Volume Number	115
Issue Number	5
e-ISSN	14320886
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-03-31
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Animal Genetics and Genomics Eukaryotic Microbiology Developmental Biology Cell Biology Biochemistry Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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