NDLI: Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint

Content Provider	Springer Nature Link
Author	Kops, Geert J. P. L. Shah, Jagesh V.
Copyright Year	2012
Abstract	With the goal of creating two genetically identical daughter cells, cell division culminates in the equal segregation of sister chromatids. This phase of cell division is monitored by a cell cycle checkpoint known as the spindle assembly checkpoint (SAC). The SAC actively prevents chromosome segregation while one or more chromosomes, or more accurately kinetochores, remain unattached to the mitotic spindle. Such unattached kinetochores recruit SAC proteins to assemble a diffusible anaphase inhibitor. Kinetochores stop production of this inhibitor once microtubules (MTs) of the mitotic spindle are bound, but productive attachment of all kinetochores is required to satisfy the SAC, initiate anaphase, and exit from mitosis. Although mechanisms of kinetochore signaling and SAC inhibitor assembly and function have received the bulk of attention in the past two decades, recent work has focused on the principles of SAC silencing. Here, we review the mechanisms that silence SAC signaling at the kinetochore, and in particular, how attachment to spindle MTs and biorientation on the mitotic spindle may turn off inhibitor generation. Future challenges in this area are highlighted towards the goal of building a comprehensive molecular model of this process.
Starting Page	509
Ending Page	525
Page Count	17
File Format	PDF
ISSN	00095915
Journal	Chromosoma
Volume Number	121
Issue Number	5
e-ISSN	14320886
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-07-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Eukaryotic Microbiology Animal Genetics and Genomics Human Genetics Cell Biology Biochemistry Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint

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Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint

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