NDLI: Comparison study of in vivo dose response to laser-driven versus conventional electron beam

Content Provider	Springer Nature Link
Author	Oppelt, Melanie Baumann, Michael Bergmann, Ralf Beyreuther, Elke Brüchner, Kerstin Hartmann, Josefin Karsch, Leonhard Krause, Mechthild Laschinsky, Lydia Leßmann, Elisabeth Nicolai, Maria Reuter, Maria Richter, Christian Sävert, Alexander Schnell, Michael Schürer, Michael Woithe, Julia Kaluza, Malte Pawelke, Jörg
Copyright Year	2015
Abstract	The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the biological consequences of this new particle beam quality, i.e. ultra-short, ultra-intense pulses. In the present work, we describe successful in vivo experiments with laser-driven electron pulses by utilization of a small tumour model on the mouse ear for the human squamous cell carcinoma model FaDu. The already established in vitro irradiation technology at the laser system JETI was further enhanced for 3D tumour irradiation in vivo in terms of beam transport, beam monitoring, dose delivery and dosimetry in order to precisely apply a prescribed dose to each tumour in full-scale radiobiological experiments. Tumour growth delay was determined after irradiation with doses of 3 and 6 Gy by laser-accelerated electrons. Reference irradiation was performed with continuous electron beams at a clinical linear accelerator in order to both validate the dedicated dosimetry employed for laser-accelerated JETI electrons and above all review the biological results. No significant difference in radiation-induced tumour growth delay was revealed for the two investigated electron beams. These data provide evidence that the ultra-high dose rate generated by laser acceleration does not impact the biological effectiveness of the particles.
Starting Page	155
Ending Page	166
Page Count	12
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	54
Issue Number	2
e-ISSN	14322099
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-01-20
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Laser particle acceleration Laser radiotherapy Tumour response to electrons Pulsed electron irradiation Small tumour model FaDu squamous cell carcinoma Tumour growth delay Biophysics and Biological Physics Effects of Radiation/Radiation Protection Environmental Physics Environmental Monitoring/Analysis Ecosystems
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

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