NDLI: Low-radiation environment affects the development of protection mechanisms in V79 cells

Content Provider	Springer Nature Link
Author	Fratini, E. Carbone, C. Capece, D. Esposito, G. Simone, G. Tabocchini, M. A. Tomasi, M. Belli, M. Satta, L.
Copyright Year	2015
Abstract	Very little is known about the influence of environmental radiation on living matter. In principle, important information can be acquired by analysing possible differences between parallel biological systems, one in a reference-radiation environment (RRE) and the other in a low-radiation environment (LRE). We took advantage of the unique opportunity represented by the cell culture facilities at the Gran Sasso National Laboratories of the Istituto Nazionale di Fisica Nucleare, where environment dose rate reduction factors in the underground (LRE), with respect to the external laboratory (RRE), are as follows: 103 for neutrons, 107 for directly ionizing cosmic rays and 10 for total γ-rays. Chinese hamster V79 cells were cultured for 10 months in both RRE and LRE. At the end of this period, all the cultures were kept in RRE for another 6 months. Changes in the activities of antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPX) and spontaneous mutation frequency at the hypoxanthine–guanine phosphoribosyl transferase (hprt) locus were investigated. The results obtained suggest that environmental radiation might act as a trigger of defence mechanisms in V79 cells, specifically those in reference conditions, showing a higher degree of defence against endogenous damage as compared to cells grown in a very low-radiation environment. Our findings corroborate the hypothesis that environmental radiation contributes to the development of defence mechanisms in today living organisms/systems.
Starting Page	183
Ending Page	194
Page Count	12
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	54
Issue Number	2
e-ISSN	14322099
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-01-31
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Radiation environment/background V79 cells Spontaneous mutation Antioxidant enzymatic activities Adaptive response Defence mechanisms Biophysics and Biological Physics Effects of Radiation/Radiation Protection Environmental Physics Environmental Monitoring/Analysis Ecosystems
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

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