NDLI: Synthesis and self-assembly behavior of novel polyaspartamide derivatives for anti-tumor drug delivery

Content Provider	Springer Nature Link
Author	Moon, Jong Rok Kim, Min Woong Kim, Dukjoon Jeong, Ji Hoon Kim, Ji Heung
Copyright Year	2010
Abstract	A series of amphiphilic graft copolymers based on polyaspartamide were synthesized by a successive aminolysis reaction of polysuccinimide using 2-diisopropylaminoethyl (DIP) and laurylamine as a pH sensitive and hydrophobic group, respectively. The pH-dependent self-assembly behavior of the aqueous copolymer solution was investigated. Nano-aggregation occurred at a pH in the vicinity of the pKa of the DIP group, which was induced by a hydrophilic–hydrophobic shift of the DIP group in solution. The mean diameter of the nano-aggregate could be modulated by changing the composition of both pendants. The mean diameter of the nanoparticles increased with increasing solution pH from 6.5 to 8. At pH 8, the mean diameter of the nanoparticles increased rapidly at the temperature above 45 °C, probably due to the change in hydrophilic–hydrophobic balance of the pH-sensitive DIP moiety. The dissolution of paclitaxel (PTX) into this amphiphilic nanoparticle was attempted and the pH-dependent release behavior was examined with the stability study of the particle. The results showed significantly faster release of PTX at pH 6.5, which is a tumoral acidic pH, than in a neutral physiological pH. These thermo- and pH-sensitive polyaspartamide derivatives have potential use as a tumor-targeting delivery.
Starting Page	63
Ending Page	71
Page Count	9
File Format	PDF
ISSN	0303402X
Journal	Colloid and Polymer Science
Volume Number	289
Issue Number	1
e-ISSN	14351536
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-10-31
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amphiphilic Graft copolymer Nanoparticle Stimuli-responsive Food Science Physical Chemistry Characterization and Evaluation of Materials Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics

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