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| Content Provider | Springer Nature Link |
|---|---|
| Author | Boeing, H. Schlehofer, B. Wahrendorf, J. |
| Copyright Year | 1997 |
| Abstract | Increasing incidence of renal cell carcinoma in Western countries raises particular attention to its etiology. Diet may be related to risk for renal cell carcinoma since obesity has been linked with this malignant condition.A case-control study with 277 incident renal cell cancer patients (ICD 189.0) and 286 population controls was conducted in the Rhein-Neckar-Odenwald area, Germany, in the period of 1989 to 1991. The core study protocol included a face-to-face interview about demographical parameters, previous diseases, medication, tobacco smoking, occupational history, occupational exposures, beverage consumption, and obesity. In addition, study participants were asked to fill in a self-administered food frequency questionnaire with 122 food items to estimate overall food intake. Fifty-six % of the cases and 74 % of the controls participated in this part of the study (n=155 cases and 212 controls). This was 47 % of the original cases (n=328) and 56 % of the controls (n=381). No selection bias could be identified with regard to age group, gender, educational status or recent BMI in the analyzed group compared with the eligible cases and controls.Relative risk (RR) estimates for tertiles of consumption revealed a significantly increased risk with increasing intake of fat spread (RR of high intake compared to low intake: 1.90 (95 % CI 1.08–3.32)). Increased risk was also found for intake of meat and meat products (RR of high intake compared to low intake: 1.71 (95 % CI 0.96–3.04)) and energy adjusted fat (RR of high intake compared to low intake: 1.64 (95 % CI 0.95–2.83)). A decreased risk was seen with increasing intake of fruit (RR of high intake compared to low intake: 0.40 (95 % CI 0.23–0.69)) and of vitamin C (RR of high intake compared to low intake: 0.62 (95 % CI 0.37–1.05)). Beverage consumption, preparation of food and eating pattern were not linked with risk of renal cell cancer. The relative risk estimates of spreading fat (sauce and vitamin C intake were tested in two models, with and without including BMI as covariate. In both models significant associations of these nutritional variables with risk for renal cell cancer remained.The current results indicate that specific food pattern associated with obesity explain differences in incidence of renal cell carcinoma in industrialized countries.Der Anstieg der Inzidenz von Nierenzellkarzinomen in den westlichen Ländern erfordert eine besondere Beachtung der Ätiologie dieses Tumors. Ernährung und das Erkrankungsrisiko für ein Nierenzellkarzinom könnten assoziiert sein, da Übergewicht als Risikofaktor für diese Erkrankung in vielen Studien identifiziert werden konnte.Eine Fall-Kontrollstudie mit 277 inzidenten Nierenkrebsfällen (ICD 189.0) und 286 bevölkerungsbezogenen Kontrollpersonen wurde im Rhein-Neckar-Odenwald-Raum, Deutschland, in der Zeit von 1989–1991 durchgeführt. Das Studienprotokoll umfaßte zunächst ein persönliches Interview über demographische Variablen, frühere Erkrankungen, Medikamenteneinnahme, Rauchen, Berufshistorie, berufsbedingte Expositionen, Getränkeaufnahme und Übergewicht. Zusätzlich wurden alle Studienteilnehmer gefragt, ob sie einen selbstausfüllbaren Häufigkeitsfragebogen mit 122 Nahrungsmitteln ausfüllen würden, um die Nahrungsaufnahme abzuschätzen. 65 % der Fälle und 74 % der Kontrollpersonen beteiligten sich an diesem Studienteil (N=155 Fälle und 212 Kontrollpersonen). Dies waren 47 % der studienrelevanten Fälle (N=328) und 56 % der Kontrollpersonen (N=381). Es konnte keine auffällige Auswahlverzerrung beobachtet werden in bezug auf Altersgruppe, Geschlecht, sozioökonomischen Status oder BMI bei der in diesen Studienteil einbezogenen Gruppe im Vergleich zu allen Fällen und Kontrollpersonen.Die relative Risiken (RR) für verschiedene Aspekte der Nahrungsaufnahme zeigten ein signifikant erhöhtes Risiko mit einer erhöhten Aufnahme von Streichfetten/Soßen (RR der hohen Aufnahme im Vergleich zur niedrigen Aufnahme: 1.90 (95 % Konfidenzintervall (95 % KI) 1.08–3.32)). Ein erhöhtes RR wurde für die Aufnahme von Fleisch und Fleischwaren beobachtet (RR der hohen Aufnahme im Vergleich zur niedrigen Aufnahme 1.71 (95 % KI 0.96–3.04)) und für energieadjustierte Fettaufnahme (RR einer hohen Aufnahme im Vergleich zu einer niedrigen Aufnahme: 1.64 (95 % KI 0.95–2.83)). Ein vermindertes RR fand sich bei einer erhöhten Aufnahme von Obst (RR einer hohen Aufnahme im Vergleich zu einer niedrigen Aufnahme: 0.40 (95 % KI 0.23–0.96)) und der Vitamin-C-Aufnahme (RR einer hohen Aufnahme im Vergleich zu einer niedrigen Aufnahme 0.62 (95 % KI 0.37–1.05)). Die Aufnahme von Getränken, Zubereitungsmethoden und andere Angaben zum Ernährungsverhalten waren nicht mit dem Risiko des Nierenzellkarzinoms assoziiert. Die RR für den Verzehr von Streichfetten/Soßen und Vitamin C wurden in zwei Modellen getestet, mit und ohne BMI als Kovariable. In beiden Modellen ergaben sich signifikante Beziehungen zwischen den Ernährungsvariablen und dem Risiko eines Nierenzellkarzinom.Diese Resultate geben Hinweise, daß bestimmte Ernährungsmuster in Verbindung mit Übergewicht herangezogen werden können, um das Auftreten von Nierenzellkarzinomen in industrialisierten Ländern zu erklären. |
| Starting Page | 3 |
| Ending Page | 11 |
| Page Count | 9 |
| File Format | |
| ISSN | 0044264X |
| Journal | European Journal of Nutrition |
| Volume Number | 36 |
| Issue Number | 1 |
| e-ISSN | 14366215 |
| Language | German |
| Publisher | Steinkopff-Verlag |
| Publisher Date | 1997-01-01 |
| Publisher Place | Darmstadt |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nierenzellkarzinom Fall-Kontrollstudie Obst Gemüse Fleisch Nutrition |
| Content Type | Text |
| Resource Type | Article |
| Subject | 2700/2701 Biochemistry Food Science |
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