NDLI: Effect of meal composition on postprandial glucagon-like peptide-1, insulin, glucagon, C-peptide, and glucose responses in overweight/obese subjects

Content Provider	Springer Nature Link
Author	Shah, Meena Franklin, Brian Adams Huet, Beverley Mitchell, Joel Bouza, Brooke Dart, Lyn Phillips, Melody
Copyright Year	2016
Abstract	Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released in response to food intake. It is unclear how meals high in protein (HP) and monounsaturated fat (HMF) affect GLP-1 response.To examine the effect of a HP versus a HMF meal on GLP-1 response.Twenty-four overweight/obese participants consumed two meals (HP: 31.9 % energy from protein; HMF: 35.2 % fat and 20.7 % monounsaturated fat) in a random order. Both meals contained the same energy and carbohydrate content. GLP-1, insulin, glucagon, C-peptide, and glucose were assessed from blood drawn in the fasting and postprandial states. The effect of meal condition on hormone and glucose responses and appetite ratings were assessed by repeated measures analysis.Statistically significant (p < 0.01) time by meal condition effect was observed on active GLP-1, total GLP-1, insulin, C-peptide, and glucagon, but not glucose (p = 0.83). Area under the curve was significantly higher during the HP versus the HMF meal conditions for active GLP-1 (23.7 %; p = 0.0007), total GLP-1 (12.2 %; p < 0.0001), insulin (54.4 %; p < 0.0001), C-peptide (14.8 %; p < 0.0001), and glucagon (40.7 %; p < 0.0001). Blood glucose was not different between the HP versus HMF conditions (−4.8 %; p = 0.11). Insulin sensitivity was higher during the HMF versus HP conditions (Matsuda index mean difference: 16.3 %; p = 0.007). Appetite ratings were not different by meal condition.GLP-1 and insulin responses were higher during the HP condition. However, no difference was found in blood glucose between conditions, and insulin sensitivity was higher during the HMF condition, indicating that a HMF meal may be optimal at regulating blood glucose in overweight/obese individuals without type 2 diabetes.
Starting Page	1053
Ending Page	1062
Page Count	10
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	56
Issue Number	3
e-ISSN	14366215
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-01-12
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	High-monounsaturated fat meal High-protein meal Meal composition Glucagon-like peptide-1 Insulin Obesity Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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The effect of meal composition on postprandial glucagon-like peptide-1 response in overweight/obese participants

The effect of meal composition on postprandial glucagon-like peptide-1 response in overweight/obese participants

The effect of meal composition on postprandial glucagon-like peptide-1 response in overweight/obese participants

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