NDLI: Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice

Please wait, while we are loading the content...

Maternal high-protein diet during pregnancy, but not during suckling, induced altered expression of an increasing number of hepatic genes in adult mouse offspring

Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice

Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model

Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study

Association between n-3 polyunsaturated fatty acids in erythrocytes and metabolic syndrome in Chinese men and women

The New Nordic Diet: phosphorus content and absorption

Multiplatform metabolomic fingerprinting as a tool for understanding hypercholesterolemia in Wistar rats

The modifying effect of vitamin C on the association between perfluorinated compounds and insulin resistance in the Korean elderly: a double-blind, randomized, placebo-controlled crossover trial

Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial

Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey

Modulation of cholesterol-related gene expression by ergosterol and ergosterol-enriched extracts obtained from Agaricus bisporus

Fasting for 3 days during the suckling–weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood

Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study

Olfactory impairment in older adults is associated with poorer diet quality over 5 years

Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes

Urolithin A causes p21 up-regulation in prostate cancer cells

Moderate physical training attenuates perinatal low-protein-induced spleen lymphocyte apoptosis in endotoxemic adult offspring rats

The effect of a cinnamon-, chromium- and magnesium-formulated honey on glycaemic control, weight loss and lipid parameters in type 2 diabetes: an open-label cross-over randomised controlled trial

Adherence to the Mediterranean diet and academic performance in youth: the UP&DOWN study

The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V

Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice

Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants

Changes in macronutrient, micronutrient, and food group intakes throughout the menstrual cycle in healthy, premenopausal women

NMR-based metabolomics highlights differences in plasma metabolites in pigs exhibiting diet-induced differences in adiposity

Urinary iodine concentration of New Zealand adults improves with mandatory fortification of bread with iodised salt but not to predicted levels

Investigation of vitamin B6 inadequacy, induced by exposure to the anti-B6 factor 1-amino d-proline, on plasma lipophilic metabolites of rats: a metabolomics approach

Do bread-crust-derived Maillard reaction products affect the retention and tissue distribution of trace elements?

Comparison of plasma alkylresorcinols (AR) and urinary AR metabolites as biomarkers of compliance in a short-term, whole-grain intervention study

Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1α/PPARγ pathway in spontaneously hypertensive rats

Mid-regional-pro-adrenomedullin plasma levels are increased in obese adolescents

Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats

Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment

Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components

Mediatory effect of circulating vaspin on resting metabolic rate in obese individuals

Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets

Erratum to: Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolymethane in human breast epithelial cell lines

European Journal of Nutrition : Volume 55, Issue 2, March 2016

European Journal of Nutrition : Volume 55, Issue 1, Supplement,March 2016

European Journal of Nutrition : Volume 55, Issue 1, February 2016

European Journal of Nutrition : Volume 54

European Journal of Nutrition : Volume 53

European Journal of Nutrition : Volume 52

European Journal of Nutrition : Volume 51

European Journal of Nutrition : Volume 50

European Journal of Nutrition : Volume 49

European Journal of Nutrition : Volume 48

European Journal of Nutrition : Volume 47

European Journal of Nutrition : Volume 46

European Journal of Nutrition : Volume 45

European Journal of Nutrition : Volume 44

European Journal of Nutrition : Volume 43

European Journal of Nutrition : Volume 42

European Journal of Nutrition : Volume 41

European Journal of Nutrition : Volume 40

European Journal of Nutrition : Volume 39

European Journal of Nutrition : Volume 38

European Journal of Nutrition : Volume 37

European Journal of Nutrition : Volume 36

Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice

Content Provider	Springer Nature Link
Author	Kanuri, Giridhar Landmann, Marianne Priebs, Josephine Spruss, Astrid Löscher, Marina Ziegenhardt, Doreen Röhl, Carolin Degen, Christian Bergheim, Ina
Copyright Year	2015
Abstract	Using ob/ob mice as a model of non-alcoholic fatty liver disease (NAFLD), we investigated the effect of moderate alcohol intake on the development of NAFLD and molecular mechanisms involved. Ob/ob mice were fed water or ethanol solution (2.5 g/kg body weight/day) for 6 weeks, and markers of liver injury, insulin signalling and adiponectin in visceral adipose tissue were determined.Whereas bodyweight and the degree of liver steatosis did not differ among ob/ob mouse groups, those consuming ethanol had markedly less macrovesicular hepatic fat accumulation, inflammatory alterations and significantly lower transaminase levels. Despite similarly elevated protein levels of tumour necrosis factor α, protein concentrations of plasminogen activator inhibitor 1 were significantly lower in livers of ob/ob mice consuming ethanol in comparison with controls. The hepato-protective property of moderate alcohol ingestion in ob/ob mice was associated with an induction of the sirtuin-1/adiponectin-signalling cascade in visceral fat tissue and an activation of Akt in the liver. Similar effects of moderate alcohol exposure were also found in vitro in 3T3-L1 and AML-12 cells.These data suggest that moderate alcohol intake may diminish the development of NAFLD through sirtuin-1/-adiponectin-dependent signalling cascades.
Starting Page	1153
Ending Page	1164
Page Count	12
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	55
Issue Number	3
e-ISSN	14366215
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-05-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adiponectin Ethanol PAI-1 SIRT1 Visceral fat Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study

The effects of moderate alcohol consumption on non-alcoholic fatty liver disease.

What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?

Low fat diet versus low carbohydrate diet for management of non-alcohol fatty liver disease: A systematic review

Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

Impact of dietary fat on the development of non-alcoholic fatty liver disease in $Ldlr^{−/−}$ mice

The Role of Macronutrients in the Pathogenesis, Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Paediatric Population—A Review

MLN4924 Treatment Diminishes Excessive Lipid Storage in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Stimulating Hepatic Mitochondrial Fatty Acid Oxidation and Lipid Metabolites.

Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)

Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice

Similar Documents

A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study

The effects of moderate alcohol consumption on non-alcoholic fatty liver disease.

What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?

Low fat diet versus low carbohydrate diet for management of non-alcohol fatty liver disease: A systematic review

Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

Impact of dietary fat on the development of non-alcoholic fatty liver disease in $Ldlr^{−/−}$ mice

The Role of Macronutrients in the Pathogenesis, Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Paediatric Population—A Review

MLN4924 Treatment Diminishes Excessive Lipid Storage in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Stimulating Hepatic Mitochondrial Fatty Acid Oxidation and Lipid Metabolites.

Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)

Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice