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Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients

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Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients

Content Provider	Springer Nature Link
Author	Grimm, H. Mertes, N. Goeters, C. Schlotzer, E. Mayer, K. Grimminger, F. Fürst, P.
Copyright Year	2005
Abstract	We assessed the effects of a novel lipid emulsion with reduced content of n–6 fatty acids (FA), increased share of MUFA and n–3 FA and supplemental vitamin E on fatty acid and leukotriene pattern in surgical patients.In a double–blind, randomized study 33 patients received isonitrogenous, isocaloric TPN over 5 postoperative days following major abdominal surgery. 19 patients received the new SMOFlipid® 20% and 14 patients a standard soybean oil emulsion (Lipovenoes® 20%, both Fresenius Kabi), each 1.5 g fat/kg body weight (BW)/d. Routine lipid biochemistry, plasma tocopherol, fatty acid pattern in plasma phospholipids, as well as leukotriene (LT) release in leukocytes were assessed. Additionally, fatty acid pattern in leukocyte and platelet phospholipids were analysed, but results are not presented.On day 6, plasma α–tocopherol (34.2 ± 10.3 vs. 17.6 ± 2.9 µmol/L) and, in plasma PL, total n–3 FA were higher (11.1 ± 1.9 vs. 4.9 ± 0.9 mol%; p < 0.05) and total n–6 FA lower (23.8 ± 2.2 vs. 31.8 ± 1.7 mol%; P < 0.05); the ratio n–3/n–6 FA being elevated (0.5 ± 0.1 vs. 0.2 ± 0.0 p < 0.05) with SMOFlipid compared to the soybean oil emulsion. The shares of EPA (3.3±1.0 vs. 0.4±0.2 mol%; p<0.05) and DHA (6.9 ± 1.8 vs. 3.7 ± 0.8 mol%; p < 0.05) were highly increased but that of arachidonic acid (AA) was unchanged with SMOFlipid while the ratio EPA/AA was increased (0.7 ± 0.2 vs. 0.1 ± 0.0 p < 0.05). LTB5 release was enhanced on day 6 (8.1 ± 5.3 vs. 1.8 ± 3.8 pmol/107 PMN, p < 0.05) and liberation of LTB4 was lowered, yet not significantly with SMOFlipid (124.0 ± 51.2 vs. 152.1 ± 68.8 pmol/107 PMN). Length of hospital stay was significantly shorter with SMOFlipid (13.4 ± 2.0 vs. 20.4 ± 10.0 days, p < 0.05).Treatment with the new emulsion SMOFlipid is well tolerated and modulates FA and leukotriene pattern suggesting favourable anti–inflammatory effects and further clinical benefits.
Starting Page	55
Ending Page	60
Page Count	6
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	45
Issue Number	1
e-ISSN	14366215
Language	English
Publisher	Steinkopff-Verlag
Publisher Date	2005-07-22
Publisher Place	Darmstadt
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	lipid emulsion TPN fish oil olive oil vitamin E immunomodulation Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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