NDLI: Dynamic variation of hemodynamic shear stress on the walls of developing chick hearts: computational models of the heart outflow tract

Content Provider	Springer Nature Link
Author	Liu, Aiping Wang, Ruikang K. Thornburg, Kent L. Rugonyi, Sandra
Copyright Year	2008
Abstract	Heart morphogenesis and growth are influenced by hemodynamic forces (wall shear stress and blood pressure) acting on the walls of the heart. Mechanisms by which hemodynamic forces affect heart development are not well understood, in part because of difficulties involved in measuring these forces in vivo. In this paper, we show how wall shear stress in the heart outflow tract (OFT) of chick embryos at an early developmental stage (HH18) are affected by changes in the geometry and motion of the OFT wall. In particular, we were interested in the effects of cardiac cushions, which are protrusions of the OFT wall toward the lumen and that are located where valves will later form. We developed idealized finite element models (FEM) of the chick OFT with and without cardiac cushions. Geometrical parameters used in these models were estimated from in vivo images obtained using optical coherence tomography (OCT) techniques. The FEMs showed significant reverse blood flow (backflow) in the OFT, consistent with experimental observations in the chick heart at HH18, and revealed that cardiac cushions decrease backflow. In addition, our FEMs showed that the spatial distribution of wall shear stress is affected by cardiac cushions, with larger absolute peak values observed at the cushions. Differences in mechanical stimuli (wall shear stress) that the cells in the cardiac cushions and elsewhere are subjected to may affect valve formation and heart development.
Starting Page	73
Ending Page	86
Page Count	14
File Format	PDF
ISSN	01770667
Journal	Engineering with Computers
Volume Number	25
Issue Number	1
e-ISSN	14355663
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-08-26
Publisher Place	London
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Heart development Chick embryo Heart outflow tract (OFT) Wall shear stress Finite element model (FEM) Optical coherence tomography (OCT) ApplicationMathematics/Computational Methods of Engineering Mechanics Calculus of Variations and Optimal Control; Optimization Systems Theory, Control Math. Applications in Chemistry Computer-Aided Engineering (CAD, CAE) and Design
Content Type	Text
Resource Type	Article
Subject	Engineering Computer Science Applications Modeling and Simulation Software

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Design optimization of 3D reinforced concrete structures having shear walls

An analysis strategy for swept solids

Guest Authorial

Automatic dimensional reduction and meshing of stiffened thin-wall structures

On the identification of kinematic hardening with reverse shear test

Function in Device Representation

Particle systems for adaptive, isotropic meshing of CAD models

Determining the parametric effectiveness of a CAD model

Web-based environment for mechanism simulation integrated with CAD system

Dynamic variation of hemodynamic shear stress on the walls of developing chick hearts: computational models of the heart outflow tract

Similar Documents

Design optimization of 3D reinforced concrete structures having shear walls

An analysis strategy for swept solids

Guest Authorial

Automatic dimensional reduction and meshing of stiffened thin-wall structures

On the identification of kinematic hardening with reverse shear test

Function in Device Representation

Particle systems for adaptive, isotropic meshing of CAD models

Determining the parametric effectiveness of a CAD model

Web-based environment for mechanism simulation integrated with CAD system

Dynamic variation of hemodynamic shear stress on the walls of developing chick hearts: computational models of the heart outflow tract