NDLI: Nanoshell-mediated laser surgery simulation for prostate cancer treatment

Content Provider	Springer Nature Link
Author	Feng, Yusheng Fuentes, David Hawkins, Andrea Bass, Jon Rylander, Marissa Nichole Elliott, Andrew Shetty, Anil Stafford, R. Jason Oden, J. Tinsley
Copyright Year	2008
Abstract	Laser surgery, or laser-induced thermal therapy, is a minimally invasive alternative or adjuvant to surgical resection in treating tumors embedded in vital organs with poorly defined boundaries. Its use, however, is limited due to the lack of precise control of heating and slow rate of thermal diffusion in the tissue. Nanoparticles, such as nanoshells, can act as intense heat absorbers when they are injected into tumors. These nanoshells can enhance thermal energy deposition into target regions to improve the ability for destroying larger cancerous tissue volumes with lower thermal doses. The goal of this paper is to present an integrated computer model using a so-called nested-block optimization algorithm to simulate laser surgery and provide transient temperature field predictions. In particular, this algorithm aims to capture changes in optical and thermal properties due to nanoshell inclusion and tissue property variation during laser surgery. Numerical results show that this model is able to characterize variation of tissue properties for laser surgical procedures and predict transient temperature fields comparable to those measured by in vivo magnetic resonance temperature imaging techniques. Note that the computational approach presented in the study is quite general and can be applied to other types of nanoparticle inclusions.
Starting Page	3
Ending Page	13
Page Count	11
File Format	PDF
ISSN	01770667
Journal	Engineering with Computers
Volume Number	25
Issue Number	1
e-ISSN	14355663
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-09-17
Publisher Place	London
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Laser-induced thermal therapy Nanoparticles Prostate cancer Laser-tissue interaction Bioheat transfer Finite element method ApplicationMathematics/Computational Methods of Engineering Mechanics Calculus of Variations and Optimal Control; Optimization Systems Theory, Control Math. Applications in Chemistry Computer-Aided Engineering (CAD, CAE) and Design
Content Type	Text
Resource Type	Article
Subject	Engineering Computer Science Applications Modeling and Simulation Software

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