NDLI: Linking physiological and cellular responses to thermal stress: β-adrenergic blockade reduces the heat shock response in fish

Content Provider	Springer Nature Link
Author	Templeman, Nicole M. LeBlanc, Sacha Perry, Steve F. Currie, Suzanne
Copyright Year	2014
Abstract	When faced with stress, animals use physiological and cellular strategies to preserve homeostasis. We were interested in how these high-level stress responses are integrated at the level of the whole animal. Here, we investigated the capacity of the physiological stress response, and specifically the β-adrenergic response, to affect the induction of the cellular heat shock proteins, HSPs, following a thermal stress in vivo. We predicted that blocking β-adrenergic stimulation during an acute heat stress in the whole animal would result in reduced levels of HSPs in red blood cells (RBCs) of rainbow trout compared to animals where adrenergic signaling remained intact. We first determined that a 1 h heat shock at 25 °C in trout acclimated to 13 °C resulted in RBC adrenergic stimulation as determined by a significant increase in cell swelling, a hallmark of the β-adrenergic response. A whole animal injection with the β2-adrenergic antagonist, ICI-118,551, successfully reduced this heat-induced RBC swelling. The acute heat shock caused a significant induction of HSP70 in RBCs of 13 °C-acclimated trout as well as a significant increase in plasma catecholamines. When heat-shocked fish were treated with ICI-118,551, we observed a significant attenuation of the HSP70 response. We conclude that circulating catecholamines influence the cellular heat shock response in rainbow trout RBCs, demonstrating physiological/hormonal control of the cellular stress response.
Starting Page	719
Ending Page	728
Page Count	10
File Format	PDF
ISSN	01741578
Journal	Journal of Comparative Physiology B
Volume Number	184
Issue Number	6
e-ISSN	1432136X
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-04-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Adrenergic stimulation HSP70 Temperature stress β-blocker ICI-118,551 Animal Physiology Biomedicine general Human Physiology Zoology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Animal Science and Zoology Ecology, Evolution, Behavior and Systematics Endocrinology

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