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| Content Provider | Springer Nature Link |
|---|---|
| Author | Moreth, Kristin Fischer, Ralf Fuchs, Helmut Gailus Durner, Valérie Wurst, Wolfgang Katus, Hugo A. Bekeredjian, Raffi Hrabě de Angelis, Martin |
| Copyright Year | 2014 |
| Abstract | Mice with genetic alterations are used in heart research as model systems of human diseases. In the last decade there was a marked increase in the recognition of genetic diversity within inbred mouse strains. Increasing numbers of inbred mouse strains and substrains and analytical variation of cardiac phenotyping methods require reproducible, high-throughput methods to standardize murine cardiovascular physiology. We describe methods for non-invasive, reliable, easy and fast to perform echocardiography and electrocardiography on awake mice. This method can be used for primary screening of the murine cardiovascular system in large-scale analysis. We provide insights into the physiological divergence of C57BL/6N, C57BL/6J, C3HeB/FeJ and 129P2/OlaHsd mouse hearts and define the expected normal values. Our report highlights that compared to the other three strains tested C57BL/6N hearts reveal features of heart failure such as hypertrophy and reduced contractile function. We found several features of the mouse ECG to be under genetic control and obtained several strain-specific differences in cardiac structure and function. |
| Starting Page | 763 |
| Ending Page | 775 |
| Page Count | 13 |
| File Format | |
| ISSN | 01741578 |
| Journal | Journal of Comparative Physiology B |
| Volume Number | 184 |
| Issue Number | 6 |
| e-ISSN | 1432136X |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2014-05-01 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Echocardiography Electrocardiography Heart Screening C57BL/6 Animal Physiology Biomedicine general Human Physiology Zoology Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Biochemistry Animal Science and Zoology Ecology, Evolution, Behavior and Systematics Endocrinology |
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