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Genome-wide association studies for multiple diseases of the German Shepherd Dog

Content Provider	Springer Nature Link
Author	Tsai, Kate L. orai, Rooksana E. Starr Moss, Alison N. Quign, Pascale Rinz, Caitlin J. Ostrander, Elaine A. Steiner, Jörg M. Murphy, Keith E. Clark, Leigh Anne
Copyright Year	2011
Abstract	The German Shepherd Dog (GSD) is a popular working and companion breed for which over 50 hereditary diseases have been documented. Herein, SNP profiles for 197 GSDs were generated using the Affymetrix v2 canine SNP array for a genome-wide association study to identify loci associated with four diseases: pituitary dwarfism, degenerative myelopathy (DM), congenital megaesophagus (ME), and pancreatic acinar atrophy (PAA). A locus on Chr 9 is strongly associated with pituitary dwarfism and is proximal to a plausible candidate gene, LHX3. Results for DM confirm a major locus encompassing SOD1, in which an associated point mutation was previously identified, but do not suggest modifier loci. Several SNPs on Chr 12 are associated with ME and a 4.7 Mb haplotype block is present in affected dogs. Analysis of additional ME cases for a SNP within the haplotype provides further support for this association. Results for PAA indicate more complex genetic underpinnings. Several regions on multiple chromosomes reach genome-wide significance. However, no major locus is apparent and only two associated haplotype blocks, on Chrs 7 and 12 are observed. These data suggest that PAA may be governed by multiple loci with small effects, or it may be a heterogeneous disorder.
Starting Page	203
Ending Page	211
Page Count	9
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	23
Issue Number	1-2
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-11-22
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zoology Cell Biology Anatomy
Content Type	Text
Resource Type	Article
Subject	Genetics

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