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| Content Provider | Springer Nature Link |
|---|---|
| Author | Marschall, Yvonne Distl, Ottmar |
| Copyright Year | 2007 |
| Abstract | Canine hip dysplasia (CHD) is a common hereditary developmental disease of the coxofemoral joints. CHD is characterized by subluxation of the femoral head and deformation of the acetabulum leading to a painful osteoarthrosis. Analyses of mode of inheritance have shown the involvement of a major gene in expression of CHD in German Shepherd dogs. Thus, a whole genome scan for quantitative trait loci (QTL) was performed in German Shepherd dogs. For this purpose 11 paternal half-sib families, including a total of 459 purebred German Shepherd dogs with sires, dams, and offspring, were genotyped for 261 microsatellites. These markers were equidistantly distributed over all 38 autosomes and the X chromosome with an average marker distance of 11.7 cM. The mean observed heterozygosity of the marker set was 50%. The CHD status for the dogs was scored according to the official rules of the Fédération Cynologique Internationale. At the genome-wide level of significance at p < 0.05, QTL for CHD were located on nine different canine chromosomes: 1, 3, 4, 8, 9, 16, 19, 26, and 33. The minimal QTL regions containing the CHD genes spanned on average 5 Mb with a range between 1 and 8.2 Mb. Chromosome-wide level of significance at p < 0.05 was found for QTL on 19 chromosomes. Further analyses can now be performed to refine these map positions of QTL already identified in German Shepherd dogs. |
| Starting Page | 861 |
| Ending Page | 870 |
| Page Count | 10 |
| File Format | |
| ISSN | 09388990 |
| Journal | Mammalian Genome |
| Volume Number | 18 |
| Issue Number | 12 |
| e-ISSN | 14321777 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2007-11-20 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Zoology Anatomy Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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