NDLI: Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Please wait, while we are loading the content...

Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus

Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Identification of evolutionarily conserved, functional noncoding elements in the promoter region of the sodium channel gene SCN8A

Ancestral bias in the Hras1 gene and distal Chromosome 7 among inbred mice

Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses

Mammalian Genome : Volume 18, Issue 9, September 2007

Mammalian Genome : Volume 18, Issue 8, August 2007

Mammalian Genome : Volume 18, Issue 6-7, July 2007

Mammalian Genome : Volume 18, Issue 5, May 2007

Mammalian Genome : Volume 18, Issue 4, April 2007

Mammalian Genome : Volume 18, Issue 3, March 2007

Mammalian Genome : Volume 18, Issue 2, February 2007

Mammalian Genome : Volume 18, Issue 1, January 2007

Mammalian Genome : Volume 17

Mammalian Genome : Volume 16

Mammalian Genome : Volume 15

Mammalian Genome : Volume 14

Mammalian Genome : Volume 13

Mammalian Genome : Volume 12

Mammalian Genome : Volume 11

Mammalian Genome : Volume 10

Mammalian Genome : Volume 9

Mammalian Genome : Volume 8

Mammalian Genome : Volume 7

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Content Provider	Springer Nature Link
Author	Weiser, Keith C. Liu, Bin Hansen, Gwenn M. Skapura, Darlene Hentges, Kathryn E. Yarlagadda, Sujatha Morse III, Herbert C. Justice, Monica J.
Copyright Year	2007
Abstract	AKXD recombinant inbred (RI) strains develop a variety of leukemias and lymphomas due to somatically acquired insertions of retroviral DNA into the genome of hematopoetic cells that can mutate cellular proto-oncogenes and tumor suppressor genes. We generated a new set of tumors from nine AKXD RI strains selected for their propensity to develop B-cell tumors, the most common type of human hematopoietic cancers. We employed a PCR technique called viral insertion site amplification (VISA) to rapidly isolate genomic sequence at the site of provirus insertion. Here we describe 550 VISA sequence tags (VSTs) that identify 74 common insertion sites (CISs), of which 21 have not been identified previously. Several suspected proto-oncogenes and tumor suppressor genes lie near CISs, providing supportive evidence for their roles in cancer. Furthermore, numerous previously uncharacterized genes lie near CISs, providing a pool of candidate disease genes for future research. Pathway analysis of candidate genes identified several signaling pathways as common and powerful routes to blood cancer, including Notch, E-protein, NFκB, and Ras signaling. Misregulation of several Notch signaling genes was confirmed by quantitative RT-PCR. Our data suggest that analyses of insertional mutagenesis on a single genetic background are biased toward the identification of cooperating mutations. This tumor collection represents the most comprehensive study of the genetics of B-cell leukemia and lymphoma development in mice. We have deposited the VST sequences, CISs in a genome viewer, histopathology, and molecular tumor typing data in a public web database called VISION (Viral Insertion Sites Identifying Oncogenes), which is located at http://www.mouse-genome.bcm.tmc.edu/vision .
Starting Page	709
Ending Page	722
Page Count	14
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	18
Issue Number	10
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-10-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zoology Anatomy Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

DOI 10.1007/s00335-007-9060-2 Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

B1 insertions as easy markers for mouse population studies

Mouse Genome Database

Orthology for comparative genomics in the mouse genome database

Gene expression study in the juvenile mouse testis: identification of stage-specific molecular pathways during spermatogenesis

From mouse genetics to systems biology

Mouse chromosome 18

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Similar Documents

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

DOI 10.1007/s00335-007-9060-2 Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

B1 insertions as easy markers for mouse population studies

Mouse Genome Database

Orthology for comparative genomics in the mouse genome database

Gene expression study in the juvenile mouse testis: identification of stage-specific molecular pathways during spermatogenesis

From mouse genetics to systems biology

Mouse chromosome 18

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma