NDLI: Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus

Please wait, while we are loading the content...

Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus

Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Identification of evolutionarily conserved, functional noncoding elements in the promoter region of the sodium channel gene SCN8A

Ancestral bias in the Hras1 gene and distal Chromosome 7 among inbred mice

Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses

Mammalian Genome : Volume 18, Issue 9, September 2007

Mammalian Genome : Volume 18, Issue 8, August 2007

Mammalian Genome : Volume 18, Issue 6-7, July 2007

Mammalian Genome : Volume 18, Issue 5, May 2007

Mammalian Genome : Volume 18, Issue 4, April 2007

Mammalian Genome : Volume 18, Issue 3, March 2007

Mammalian Genome : Volume 18, Issue 2, February 2007

Mammalian Genome : Volume 18, Issue 1, January 2007

Mammalian Genome : Volume 17

Mammalian Genome : Volume 16

Mammalian Genome : Volume 15

Mammalian Genome : Volume 14

Mammalian Genome : Volume 13

Mammalian Genome : Volume 12

Mammalian Genome : Volume 11

Mammalian Genome : Volume 10

Mammalian Genome : Volume 9

Mammalian Genome : Volume 8

Mammalian Genome : Volume 7

Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus

Content Provider	Springer Nature Link
Author	Pretsch, Walter Favor, Jack
Copyright Year	2007
Abstract	The first mutations causing hereditary glyceraldehyde-3-phosphate dehydrogenase (GAPDH) deficiency in the mouse are described. In the course of various mutagenicity experiments with chemical mutagens and irradiation, nine independent mutations causing approximately 50–55% residual activity in blood compared to wild type were identified at the Gapdh structural locus on chromosome 6. Breeding experiments displayed an autosomal semidominant mode of inheritance for all mutants. Two mutations are homozygous viable producing a GAPDH residual activity of less than 10%. Mortality of the remaining seven homozygous lethal lines occurs at an early postimplantation stage of development. The physiologic and hematologic analyses provided no indication for further altered traits in heterozygotes or homozygotes. The molecular characterization showed base substitutions resulting in amino acid exchanges in seven mutations, in one mutation a transversion creating a stop codon caused a truncated protein of 89 amino acids and two deletions generating truncated proteins of 73 and 9 amino acids, respectively.
Starting Page	686
Ending Page	692
Page Count	7
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	18
Issue Number	10
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-09-17
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zoology Anatomy Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus

Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations

Characterization of Triosephosphate Isomerase Mutants with Reduced Enzyme Activity in Mus Musculus

Isolation and characterization of Glyceraldehyde-3-phosphate dehydrogenase from the common octopus (Octopus vulgaris Cuvier, 1797)

Immunolocalization of glyceraldehyde-3-phosphate dehydrogenase inArabidopsis thaliana

Gene flow of unique sequences between Mus musculus domesticus and Mus spretus

Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus

Expression profiles of glyceraldehyde-3-phosphate dehydrogenase from Clonorchis sinensis: a glycolytic enzyme with plasminogen binding capacity

Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17

Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus

Similar Documents

Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus

Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations

Characterization of Triosephosphate Isomerase Mutants with Reduced Enzyme Activity in Mus Musculus

Isolation and characterization of Glyceraldehyde-3-phosphate dehydrogenase from the common octopus (Octopus vulgaris Cuvier, 1797)

Immunolocalization of glyceraldehyde-3-phosphate dehydrogenase inArabidopsis thaliana

Gene flow of unique sequences between Mus musculus domesticus and Mus spretus

Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus

Expression profiles of glyceraldehyde-3-phosphate dehydrogenase from Clonorchis sinensis: a glycolytic enzyme with plasminogen binding capacity

Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17

Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus