NDLI: A comparative study on the druggability of Schiff bases and dithiocarbamate derivatives of chitosan

Content Provider	Springer Nature Link
Author	ushad, T. Alikutty, P. Basila, H. Rajan, Vijisha K. Muraleedharan, K. Abdul Mujeeb, V. M.
Copyright Year	2016
Abstract	The druggability of the Schiff bases and dithiocarbamate derivatives of chitosan was examined; the oral bioavailability and bioactivity of all these molecules against selected drug targets were investigated, as well as ADME/Tox studies were conducted. It was observed that the Lipinski’s rule of five was satisfied by all the molecules. The Schiff bases and dithiocarbamate derivatives of chitosan also show good bioactivity score for protease and enzyme inhibition. The ADME/Tox studies conducted show that almost all the derivatives are free from toxicity risks, except citral- and sulfur-containing derivatives. Substitution of the –SH group by –NH2 gives better positive results in toxicology studies. From this study, it has been observed that these molecules exhibit fairly good drug score and are orally viable molecules. The mechanism driving their bioactivity might be chelation of chitosan and its derivatives with essential metal ions. Chitosan and the derivatives studied can serve as good lead molecules for further research.
Starting Page	2165
Ending Page	2177
Page Count	13
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	73
Issue Number	8
e-ISSN	14362449
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-01-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chitosan schiff base Dithiocarbamate derivatives Druggability Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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