NDLI: A biocompatible glucose-containing ABC block terpolymer: synthesis, characterization and its properties in solution

Content Provider	Springer Nature Link
Author	Zhu, Jinli Lu, Minlei Wang, Miao Ding, Jinjin Sun, Tongming Tang, Yanfeng Zhang, Yuejun
Copyright Year	2016
Abstract	A novel glucose-containing ABC block terpolymer, poly(N-isopropyl acrylamide)-block-poly(acryloyl glucofuranose)-block-poly(acrylic acid) (PNAA) was synthesized by sequential reversible addition–fragmentation chain transfer polymerization. 2-Dodecylsulfanylthiocarbonylsulfanyl-2-methylpropionic acid was synthesized and was used as a chain transfer agent. The structures were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance and gel permeation chromatography. Transmission electron microscopy and the phase transition behaviour confirmed that the block terpolymers could directly aggregate into spherical micelles. The results of dynamic light scattering and in vitro drug release experiments demonstrated that the content of the poly(3-O-acryloyl-glucofuranose) segments significantly influences the size of the micelles, the critical micelle concentration (CMC) and the drug release behaviours of the PNAA hydrogels. When the monomer molar ratios of acrylic acid/3-O-acryloyl-glucofuranose/N-isopropyl acrylamide are 4:2:14, the micelle size of PNAA is 292.3 nm, the CMC is the lowest (0.056 mg/mL), and the amount of cumulative drug release is up to 81 %. In vivo biocompatibility tests and in vitro cytotoxicity tests showed that the synthesized block terpolymer had no apparent cytotoxicity.
Starting Page	2373
Ending Page	2390
Page Count	18
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	73
Issue Number	8
e-ISSN	14362449
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-06-13
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biocompatible Glucose-containing ABC block terpolymer RAFT polymerization Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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