NDLI: Anomalous Viscosity Behavior in Aqueous Solutions of Hyaluronic Acid

Content Provider	Springer Nature Link
Author	Maleki, Atoosa Kjøniksen, Anna Lena Nyström, Bo
Copyright Year	2007
Abstract	Effects of steady shear flows on intermolecular interactions in dilute and semidilute aqueous solutions of hyaluronic acid (HA) are reported. Pronounced shear thinning behavior is observed for solutions of HA at high shear rates, and no hysteresis effects are detected upon the subsequent return to low shear rates. With the aid of the asymmetric flow field-flow fractionation (AFFFF) technique, it is shown that mechanical degradation of the polymer does not take place in these shear viscosity experiments, even at high shear rates. The low shear rate viscosity of a semidilute HA solution decreases by approximately 40% when the temperature is increased from 10 °C to 45 °C. It is shown that when a dilute HA solution is exposed to a low fixed shear rate (0.001 s-1), a marked viscosification occurs in the course of time and prominent intermolecular complexes are formed. It is argued that shear-induced alignment and stretching of polymer chains promote the evolution of hydrogen-bonded structures, where cooperative zipping of stretched chains generates a network. At a higher constant shear rate (0.1 s-1), the viscosity decreases as time goes because of the alignment of the polymer chains, but the higher shear flow perturbation prevents the chains in dilute solutions from building up association complexes. The viscosity of an entangled HA solution is not changed in the considered time window at this shear rate, but the network structures breakdown at the highest shear rate (1000 s-1), and then they are restored upon return to a low shear rate.
Starting Page	217
Ending Page	226
Page Count	10
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	59
Issue Number	2
e-ISSN	14362449
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-03-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biopolymers hyaluronic acid rheology shear-induced viscosification aqueous solutions Polymer Sciences Characterization and Evaluation of Materials Soft Matter, Complex Fluids Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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