NDLI: Niosomes as transdermal drug delivery system for celecoxib: in vitro and in vivo studies

Content Provider	Springer Nature Link
Author	Auda, Sayed H. Fathalla, Dina Fetih, Gihan El Badry, Mahmoud Shakeel, Faiyaz
Copyright Year	2015
Abstract	Nonionic surfactant vesicles containing celecoxib (CXB) as an anti-inflammatory drug were prepared using, Span 60 or Span 40 and cholesterol in the ratios of 1:0, 1:1 and 1:2. Prepared vesicles were characterized for encapsulation efficiency, particle size and drug release. The drug encapsulation efficiencies varied from 60.55 to 80.35 %. The vesicle size ranged from 170 to 235 nm. The high encapsulation was achieved by the ratio 1:1 of span 60:cholesterol and this formula showed significant in vitro release of the drug (80 %) as compared to other forms (P < 0.05). Among niosomal gels investigated, poloxamer 407 niosomal gel showed significant drug release (72 % after 12 h) over the other forms (P < 0.05). The results also showed that the release of CXB from the niosomes and niosomal gels obeyed the Higuchi’s diffusion model. The anti-inflammatory activity of the drug from different niosomal gel formulations was also studied using Carrageenan-induced rat paw edema method. The results showed that there is significant anti-inflammatory activity (75.45 %) of the poloxamer niosomal gel on rat paw edema (P < 0.05).
Starting Page	1229
Ending Page	1245
Page Count	17
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	73
Issue Number	5
e-ISSN	14362449
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-11-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Celecoxib Niosomal gel Kinetic study Skin permeation Anti-inflammatory activity Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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