NDLI: Sol–gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system

Content Provider	Springer Nature Link
Author	Czarbaj, Katarzyna
Copyright Year	2010
Abstract	Silica, silica/polydimethylsiloxane and silica/polydimethylsiloxane/calcium xerogels were examined as polymeric carriers for the controlled release of drug—Metronidazole. Characterization assays comprised analysis of the matrix by Fourier transform infrared spectroscopy (FTIR), determining the specific surface area of solids (BET) and scanning electron microscope (SEM) techniques and further monitoring in the ultraviolet and visible light regions (UV–Vis) of the in vitro release of the drug over time. Using tetramethoxysilane (TMOS) as a precursor of silica matrix and polydimethylsiloxane (PDMS) and calcium ions as additives, xerogels with different morphology and physical properties were obtained. The applied modifications diminished the porosity and hydrophilicity of the silica matrix as well as reduced the release of drug. Based on the presented results of this study, it may be stated that applied xerogel matrices, pure silica (SiO2) and modified silica (SiO2–CaO, SiO2–PDMS and SiO2–CaO–PDMS), could be promising candidates for the formulation in local delivery systems.
Starting Page	223
Ending Page	237
Page Count	15
File Format	PDF
ISSN	01700839
Journal	Polymer Bulletin
Volume Number	66
Issue Number	2
e-ISSN	14362449
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-07-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sol–gel method Silica xerogels Drug delivery Controlled release Physical Chemistry Characterization and Evaluation of Materials Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Condensed Matter Physics Polymers and Plastics

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