NDLI: Regulatory T cells in lung transplantation

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Springer Seminars in Immunopathology : Volume 39

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Transplantation and tolerance

Clinical transplantation tolerance

Loss of tolerance to self after transplant

Inflammation and transplantation tolerance

Regulatory T cells in lung transplantation—an emerging concept

Role of Th17 cells and IL-17 in lung transplant rejection

Lung transplantation: infection, inflammation, and the microbiome

Steroids in kidney transplant patients

The role of innate immunity in donor organ procurement

Assessment of kidney organ quality and prediction of outcome at time of transplantation

Special issues in the management and selection of the donor for lung transplantation

Advances of genomic science and systems biology in renal transplantation: a review

Springer Seminars in Immunopathology : Volume 33, Issue 1, January 2011

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Regulatory T cells in lung transplantation—an emerging concept

Content Provider	Springer Nature Link
Author	Neujahr, David C. Larsen, Christian P.
Copyright Year	2011
Abstract	Lung transplantation represents an option for patients with a variety of end-stage lung diseases. While surgical advances have led to improvements in short-term survival, long-term survival is limited by chronic rejection termed bronchiolitis obliterans syndrome (BOS). A growing body of work is devoted to determining why some patients develop BOS. One avenue of interest that has emerged recently is the role that regulatory T cells (Tregs) may have in protection from BOS. In this review, we will discuss the evidence that Tregs are relevant to outcomes following transplant. We will discuss the relevant animal models, in vitro assays, and human observational studies that support a role for Tregs. We will also explore the interplay between injurious T cells such as Th17 cells and Tregs as well as the effect that additional cell types and chemokines have on the balance between inflammation and regulation. Finally, we will review emerging therapies which may harness the ability of Tregs to lessen the effects of BOS.
Starting Page	117
Ending Page	127
Page Count	11
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	33
Issue Number	2
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-03-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lung transplantation Bronchiolitis obliterans Tregs FoxP3 Th17 Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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