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| Content Provider | Springer Nature Link |
|---|---|
| Author | Steiner, Robert W. Awdishu, Linda |
| Copyright Year | 2011 |
| Abstract | Any evaluation of steroids in kidney transplantation is hampered by individual variability in metabolism, the lack of clinically available steroid blood levels, and overall little attention to steroid exposure. Many feel that steroids were an essential part of chronic immunosuppression in past decades but may no longer be necessary in low-risk populations when our newer and more potent drugs are used. Potential differences in long-term outcome will be unapparent in short-term antibody induction studies in low-risk patients, particularly with low on steroid doses, as may have happened in the recent, well-done Astellas trial. In many studies, the evidence for the superiority of mycophenolate (MMF) and tacrolimus (TAC) was not as strong as the evidence for the benefit of steroids in the Canadian cyclosporine study. As the practice of steroid withdrawal has increased, we have not seen the improvement in long-term graft survival that many expected with our newer agents. Steroids have immunosuppressive effects even in doses that are low by historic standards, and side effects may not justify their abandonment. |
| Starting Page | 157 |
| Ending Page | 167 |
| Page Count | 11 |
| File Format | |
| ISSN | 18632297 |
| Journal | Springer Seminars in Immunopathology |
| Volume Number | 33 |
| Issue Number | 2 |
| e-ISSN | 18632300 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2011-02-18 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Kidney transplantation Steroids Immunosuppression Immunology Internal Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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