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| Content Provider | Springer Nature Link |
|---|---|
| Author | Khan, Shaniya H. Badovinac, Vladimir P. |
| Copyright Year | 2015 |
| Abstract | Memory CD8 T cells play a critical role in providing protection to immune hosts by orchestrating rapid elimination of pathogen-infected cells after re-infection. Systemic bacterial infection with Listeria monocytogenes has been a favored approach for researchers to characterize pathogen-specific CD8 T cell responses, and in-depth understanding of L. monocytogenes biology has provided invaluable experimental tools that have been used to increase our understanding of memory CD8 T cell differentiation. Here, we describe how the tools from this murine model system of infection have been utilized to characterize pathogen-specific CD8 T cells in inbred and genetically diverse outbred hosts as they undergo naïve-to-memory CD8 T cell differentiation in vivo. We also discuss how studying L. monocytogenes-evoked CD8 T cell responses have provided insight on the degree of diminished T cell immunity in clinically relevant conditions such as sepsis and obesity. Overall, this review will highlight how infection with the intracellular pathogen L. monocytogenes has enabled analysis of systemic CD8 T cell responses and greatly contributed to what is known about memory CD8 T cell generation and differentiation. |
| Starting Page | 301 |
| Ending Page | 310 |
| Page Count | 10 |
| File Format | |
| ISSN | 18632297 |
| Journal | Springer Seminars in Immunopathology |
| Volume Number | 37 |
| Issue Number | 3 |
| e-ISSN | 18632300 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2015-04-10 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | CD8 T cells Memory Inflammation Sepsis Obesity CD11a Interferon-γ Immunology Internal Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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