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CD8+ T cell immune response against non-viral pathogens

From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells

Pathogenic CD8+ T cells in experimental cerebral malaria

CD8+ T cells in Trypanosoma cruzi infection

CD8 T cells and Mycobacterium tuberculosis infection

CD8+ T cells in cutaneous leishmaniasis: the good, the bad, and the ugly

Characteristics and critical function of CD8+ T cells in the Toxoplasma-infected brain

CD8+ T cell immunity in an encephalitis model of Toxoplasma gondii infection

Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism

The role of CD8 T lymphocytes in rickettsial infections

Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses

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CD8+ T cells in Trypanosoma cruzi infection

Content Provider	Springer Nature Link
Author	Tarleton, Rick L.
Copyright Year	2015
Abstract	Trypanosoma cruzi infection and Chagas disease remains among the most neglected of the neglected tropical diseases. Despite this, studies of the immune response to T. cruzi have provided new insights in immunology and guidance for approaches for prevention and treatment of the disease. T. cruzi represents one of the very best systems in which to study CD8+ T cell biology; mice, dogs, and primates (and many other mammals) are all natural hosts for this parasite, the robust T cell responses generated in these hosts can be readily monitored using the full range of cutting edge techniques, and the parasite can be easily modified to express (or not) a variety of tags, reporters, immune enhances, and endogenous or model antigens. The infection in most hosts is characterized by vigorous and largely effective immune responses, including CD8+ T cells capable of controlling T. cruzi at the level of the infected host cells. However, this immune control is only partially effective and most hosts maintain a low level infection for life. This review addresses the interplay of highly effective CD8+ T cell responses with elaborate pathogen immune evasion mechanisms, including the generation and simultaneous expression of highly variant CD8+ T cell targets and a host cell invasion mechanisms that largely eludes innate immune detection.
Starting Page	233
Ending Page	238
Page Count	6
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	37
Issue Number	3
e-ISSN	18632300
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-04-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CD8+ T cells Trypanosoma cruzi Chagas disease Immunodominance PAMPs DAMPs Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Exhausted PD-1+ TOX+ CD8+ T Cells Arise Only in Long-Term Experimental Trypanosoma cruzi Infection

IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection

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CD8+ T Cell Response Quality Is Related to Parasite Control in an Animal Model of Single and Mixed Chronic Trypanosoma cruzi Infections

Tolerogenic Dendritic Cells Reduce Cardiac Inflammation and Fibrosis in Chronic Chagas Disease

Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection

CD8+ T cells in Trypanosoma cruzi infection

CD8+ T cells in Trypanosoma cruzi infection

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