NDLI: Immunopathology of the human pancreas in type-I diabetes

Content Provider	Springer Nature Link
Author	Richardson, Sarah J. Willcox, Abby Bone, Adrian J. Morgan, el G. Foulis, Alan K.
Copyright Year	2010
Abstract	Type 1 diabetes is a chronic autoimmune disease characterised by the selective destruction of pancreatic beta (β) cells. The understanding of the aetiology of this disease has increased dramatically in recent years by the study of tissue recovered from patients, from analysis of the responses of isolated islet and β-cells in tissue culture and via the use of animal models. However, knowledge of the immunopathology of type 1 diabetes in humans is still relatively deficient due largely to the difficulty of accessing appropriate samples. Here we review the state of current knowledge in relation to the histopathological features of the disease in humans. We focus specifically on recent-onset type 1 diabetes cases since in such patients, evidence of the ongoing disease process is still present. We chart the progression of the disease by describing the characteristic features of the pancreas, consider the sequence of immune cell infiltration and discuss the abnormalities of MHC antigen expression. The possibility that these changes might derive from a persistent enteroviral infection of the islet beta cells is examined.
Starting Page	9
Ending Page	21
Page Count	13
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	33
Issue Number	1
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-04-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Insulitis Beta-cell death Enterovirus Recent-onset type 1 diabetes MHC Chemokine Pancreatic histology Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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