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  1. Springer Seminars in Immunopathology
  2. Springer Seminars in Immunopathology : Volume 37
  3. Springer Seminars in Immunopathology : Volume 37, Issue 5, September 2015
  4. Epigenetics and systemic sclerosis
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Springer Seminars in Immunopathology : Volume 39
Springer Seminars in Immunopathology : Volume 38
Springer Seminars in Immunopathology : Volume 37
Springer Seminars in Immunopathology : Volume 37, Issue 6, November 2015
Springer Seminars in Immunopathology : Volume 37, Issue 5, September 2015
The immunopathology of systemic sclerosis
Genetics of systemic sclerosis
Epigenetics and systemic sclerosis
Environmental risk factors of systemic sclerosis
Update on biomarkers in systemic sclerosis: tools for diagnosis and treatment
Vasculopathy in scleroderma
Gene expression profiling offers insights into the role of innate immune signaling in SSc
Role of innate immune system in systemic sclerosis
The role of the acquired immune response in systemic sclerosis
Functional autoantibodies in systemic sclerosis
Cytokines in the immunopathology of systemic sclerosis
Matrix remodeling in systemic sclerosis
Fibrogenesis, novel lessons from animal models
Springer Seminars in Immunopathology : Volume 37, Issue 4, July 2015
Springer Seminars in Immunopathology : Volume 37, Issue 3, May 2015
Springer Seminars in Immunopathology : Volume 37, Issue 2, March 2015
Springer Seminars in Immunopathology : Volume 37, Issue 1, January 2015
Springer Seminars in Immunopathology : Volume 36
Springer Seminars in Immunopathology : Volume 35
Springer Seminars in Immunopathology : Volume 34
Springer Seminars in Immunopathology : Volume 33
Springer Seminars in Immunopathology : Volume 32
Springer Seminars in Immunopathology : Volume 31
Springer Seminars in Immunopathology : Volume 30
Springer Seminars in Immunopathology : Volume 29
Springer Seminars in Immunopathology : Volume 28
Springer Seminars in Immunopathology : Volume 27
Springer Seminars in Immunopathology : Volume 26
Springer Seminars in Immunopathology : Volume 25
Springer Seminars in Immunopathology : Volume 24
Springer Seminars in Immunopathology : Volume 23
Springer Seminars in Immunopathology : Volume 22
Springer Seminars in Immunopathology : Volume 21
Springer Seminars in Immunopathology : Volume 20
Springer Seminars in Immunopathology : Volume 19
Springer Seminars in Immunopathology : Volume 18

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Epigenetics and systemic sclerosis

Content Provider Springer Nature Link
Author Altorok, Nezam Kahaleh, Bashar
Copyright Year 2015
Abstract Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vascular injury, activation of the immune system, and diffuse tissue fibrosis. The precise etiology of SSc is undetermined, but there is evidence suggestive of a connection between environmental factors and SSc pathogenesis. In general, harmful environmental factors are sensed by the epigenetic regulatory mechanisms that alter host gene expression leading to the emergence of disease-specific phenotype. There are three epigenetic mechanisms involved in gene regulation: DNA methylation, histone modifications, and microRNAs. Although there is evidence that SSc phenotype could be, to a some degree, determined by genetic variants, it is clear now that non-genetic factors outweigh the genetic risk in SSc. Accordingly, the environment can trigger epigenetic regulation that in turn establishes a molecular framework linking environmental exposures to genetics, leading to the disease process, possibly in a genetically predisposed host. Although we have just begun to appreciate the potential role of epigenetics in SSc, many important and promising clues have been observed. In this review, we will summarize the work that has been done in the field of epigenetic regulation in SSc, and we will discuss possible factors and mechanisms that may lead to epigenetic dysregulation in SSc.
Starting Page 453
Ending Page 462
Page Count 10
File Format PDF
ISSN 18632297
Journal Springer Seminars in Immunopathology
Volume Number 37
Issue Number 5
e-ISSN 18632300
Language English
Publisher Springer Berlin Heidelberg
Publisher Date 2015-07-11
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Scleroderma Systemic sclerosis Epigenetics DNA methylation Histone modification MicroRNA Immunology Internal Medicine
Content Type Text
Resource Type Article
Subject Immunology and Allergy Immunology
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