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Springer Seminars in Immunopathology : Volume 39

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Immunodermatology

The skin barrier as an innate immune element

Toll-like receptors in the skin

Antimicrobial peptides: natural effectors of the innate immune system

Adhesion molecules in cutaneous immunity

T cell tolerance to the skin: a central role for central tolerance

Photoimmunology—illuminating the immune system through photobiology

Topical vaccination: the skin as a unique portal to adaptive immune responses

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Toll-like receptors in the skin

Content Provider	Springer Nature Link
Author	Miller, Lloyd S. Modlin, Robert L.
Copyright Year	2007
Abstract	Toll-like receptors (TLRs) are important pattern-recognition receptors involved in host defense against a variety of pathogenic microorganisms. Activation of TLRs leads to the production of cytokines, chemokines, antimicrobial peptides, and upregulation costimulatory and adhesion molecules involved in innate and adaptive immune responses. TLRs are expressed on a variety of cell types found in the skin, including keratinocytes and Langerhans cells in the epidermis, resident and trafficking immune-system cells such as macrophages, dendritic cells, T and B cells, and mast cells in the dermis, endothelial cells of the skin microvasculature, and skin stromal cells such as fibroblasts and adipocytes. There have been an increasing number of reports demonstrating that TLRs play a key role in cutaneous host defense mechanisms against bacterial, fungal, and viral pathogens. In addition, TLRs have also been implicated in the pathophysiology of various inflammatory skin diseases.
Starting Page	15
Ending Page	26
Page Count	12
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	29
Issue Number	1
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-02-21
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Toll-like receptors TLR Skin Cutaneous Pattern-recognition receptors Internal Medicine Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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