NDLI: B cell-mediated pathogenesis of ANCA-mediated vasculitis

Please wait, while we are loading the content...

Springer Seminars in Immunopathology : Volume 39

Springer Seminars in Immunopathology : Volume 38

Springer Seminars in Immunopathology : Volume 37

Springer Seminars in Immunopathology : Volume 36

Springer Seminars in Immunopathology : Volume 36, Issue 6, November 2014

Springer Seminars in Immunopathology : Volume 36, Issue 5, September 2014

Springer Seminars in Immunopathology : Volume 36, Issue 4, July 2014

Springer Seminars in Immunopathology : Volume 36, Issue 3, May 2014

Introduction: B cell-mediated autoimmune diseases

Plasma cells in immunopathology: concepts and therapeutic strategies

Targeting B cells and autoantibodies in the therapy of autoimmune diseases

The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved

The pathogenic potential of autoreactive antibodies in rheumatoid arthritis

B cell-mediated pathogenesis of ANCA-mediated vasculitis

B cells in MS and NMO: pathogenesis and therapy

Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases

Rationale for B cell targeting in SLE

Springer Seminars in Immunopathology : Volume 36, Issue 2, March 2014

Springer Seminars in Immunopathology : Volume 36, Issue 1, January 2014

Springer Seminars in Immunopathology : Volume 35

Springer Seminars in Immunopathology : Volume 34

Springer Seminars in Immunopathology : Volume 33

Springer Seminars in Immunopathology : Volume 32

Springer Seminars in Immunopathology : Volume 31

Springer Seminars in Immunopathology : Volume 30

Springer Seminars in Immunopathology : Volume 29

Springer Seminars in Immunopathology : Volume 28

Springer Seminars in Immunopathology : Volume 27

Springer Seminars in Immunopathology : Volume 26

Springer Seminars in Immunopathology : Volume 25

Springer Seminars in Immunopathology : Volume 24

Springer Seminars in Immunopathology : Volume 23

Springer Seminars in Immunopathology : Volume 22

Springer Seminars in Immunopathology : Volume 21

Springer Seminars in Immunopathology : Volume 20

Springer Seminars in Immunopathology : Volume 19

Springer Seminars in Immunopathology : Volume 18

B cell-mediated pathogenesis of ANCA-mediated vasculitis

Content Provider	Springer Nature Link
Author	Jennette, J. Charles Falk, Ronald J.
Copyright Year	2014
Abstract	B cells and their progeny that produce and release anti-neutrophil cytoplasmic autoantibodies (ANCA) are the primary cause for an aggressive form of necrotizing small vessel vasculitis. Cytoplasmic ANCA antigens are released at the surface and in the microenvironment of cytokine-primed neutrophils. Binding of ANCA to ANCA antigens activates neutrophils by both Fc receptor engagement and direct Fab’2 binding to antigen on the cell surface. ANCA-activated neutrophils release factors that induce alternative complement pathway activation, which establishes a potent inflammatory amplification loop that causes severe necrotizing vascular inflammation. The origin of the ANCA autoimmune response is unknown but appears to involve genetically determined HLA specificities that allow the autoimmune response to develop. One putative immunogenic mechanism begins with an immune response to a peptide that is complementary to the autoantigen and evolves through an anti-idiotypic network to produce autoantibodies to the autoantigen. Another putative immunogenic mechanism begins with an immune response to a microbe-derived molecular mimic of the autoantigen resulting in antibodies that cross-react with the autoantigen. Release of neutrophil extracellular traps, apoptosis, and increased granule protein expression of ANCA antigens may facilitate the initiation of an ANCA autoimmune response, augment established pathogenic ANCA production, or both. The ANCA B cell autoimmune response is facilitated by quantitatively and qualitatively impaired T cell and B cell suppression and by release from activated neutrophils of B cell-activating factors that enhance B cell proliferation and retard B cell apoptosis.
Starting Page	327
Ending Page	338
Page Count	12
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	36
Issue Number	3
e-ISSN	18632300
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-04-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anti-neutrophil cytoplasmic autoantibodies MPO-ANCA PR3-ANCA Vasculitis Microscopic polyangiitis Granulomatosis with polyangiitis Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The immunopathology of ANCA-associated vasculitis

Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis

Relevance of Combined Clinicopathologic Phenotype and Antineutrophil Cytoplasmic Autoantibody Serotype in the Diagnosis of Antineutrophil Cytoplasmic Autoantibody Vasculitis.

Natural Killer Cells in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - A Review of the Literature

Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides

Patient perceptions of glucocorticoids in anti-neutrophil cytoplasmic antibody-associated vasculitis

Kaposi sarcoma in anti-neutrophil cytoplasmic antibody-associated vasculitis: a case-based review.

Polyangiitis overlap syndrome: a rare clinical entity.

Treatment of ANCA-associated vasculitides (AAV).

B cell-mediated pathogenesis of ANCA-mediated vasculitis

Similar Documents

The immunopathology of ANCA-associated vasculitis

Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis

Relevance of Combined Clinicopathologic Phenotype and Antineutrophil Cytoplasmic Autoantibody Serotype in the Diagnosis of Antineutrophil Cytoplasmic Autoantibody Vasculitis.

Natural Killer Cells in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - A Review of the Literature

Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides

Patient perceptions of glucocorticoids in anti-neutrophil cytoplasmic antibody-associated vasculitis

Kaposi sarcoma in anti-neutrophil cytoplasmic antibody-associated vasculitis: a case-based review.

Polyangiitis overlap syndrome: a rare clinical entity.

Treatment of ANCA-associated vasculitides (AAV).

B cell-mediated pathogenesis of ANCA-mediated vasculitis