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Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody–Associated Vasculitis
| Content Provider | MDPI |
|---|---|
| Author | Solbritt, Rantapää-Dahlqvist Esberg, Anders Johansson, Linda Berglin, Ewa Mohammad, Aladdin J. Jonsson, Andreas P. Dahlqvist, Johanna Stegmayr, Bernd Johansson, Ingegerd |
| Copyright Year | 2022 |
| Description | Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral bacterial species/subspecies were screened using immunoblotting in plasma/serum in pre-symptomatic AAV-individuals (n = 85), matched controls, and established AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was sequenced from 16s rDNA amplicons. Information on dental status was extracted from a national register. IgG levels against oral bacteria were lower in established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, compared to controls, a higher abundance of periodontitis-associated species paralleling more signs of periodontitis in established AAV-patients than controls. Saliva microbiota in acute-AAV showed higher within-sample diversity but fewer detectable amplicon-sequence variants and taxa in their core microbiota than controls. Acute-AAV was not associated with increased abundance of periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral bacteria differed between pre-AAV, established AAV, and controls, and microbiota profiles between acute AAV and controls. The IgG shift from a pre-symptomatic stage to established disease cooccurred with treatment of immunosuppression and/or antibiotics. |
| Starting Page | 1572 |
| e-ISSN | 20762607 |
| DOI | 10.3390/microorganisms10081572 |
| Journal | Microorganisms |
| Issue Number | 8 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-04 |
| Access Restriction | Open |
| Subject Keyword | Microorganisms Dentistry and Oral Surgery Igg Oral Microbiota Vasculitis Caries Periodontal Disease Anti-neutrophil Cytoplasmatic Antibody–associated Vasculitis Granulomatosis with Polyangiitis (gpa) Microscopic Polyangiitis (mpa) Proteinase 3 (pr3)-anca Myeloperoxidase (mpo)-anca |
| Content Type | Text |
| Resource Type | Article |
