NDLI: The discovery of immunostimulatory DNA sequence

Content Provider	Springer Nature Link
Author	Yamamoto, Saburo Yamamoto, Toshiko Tokunaga, Tohru
Copyright Year	2000
Abstract	The concept of immunostimulatory DNA sequence was born in a long series of studies on BCG-mediated tumor resistance. DNA purified from BCG inhibited the growth of various animal tumors, augmented cell activity and induced IFN from mouse spleen cells. Further, we found two remarkable facts (1) DNA from bacteria, but not animals and plants, showed the above-mentioned immunogical activity, and (2) the activity was completely dependent on particular base sequences having CpG motifs. Research interests of immunostimulatory DNA sequences were galvanized in 1995 by the report of Krieg showing murine B cell activation with bacterial DNA containing CpG motifs [9]. Within a short period of time, a huge number of papers have been published in this field, and the study has expanded rapidly and widely. Now, it includes a number of research fields, for example, host-defense mechanisms against infection, allergy, autoimmune diseases, cytokine networks, plasmid vaccination, and therapeutic application of certain diseases [5, 8, 11, 15, 16, 29]. The response of higher animals against immunostimulatory DNA must be the most primitive but important mechanism for self-nonself discrimination against foreign DNA.
Starting Page	11
Ending Page	19
Page Count	9
File Format	PDF
ISSN	03444325
Journal	Springer Seminars in Immunopathology
Volume Number	22
Issue Number	1-2
e-ISSN	14322196
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-01-01
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Immunology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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