NDLI: Development of a glutathione production process from proteinaceous biomass resources using protease-displaying Saccharomyces cerevisiae

Content Provider	Springer Nature Link
Author	Hara, Kiyotaka Y. Kim, Songhee Yoshida, Hideyo Kiriyama, Kentaro Kondo, Takashi Okai, Naoko Ogi, Chiaki Fukuda, Hideki Kondo, Akihiko
Copyright Year	2011
Abstract	Glutathione is a valuable tri-peptide that is widely used in the pharmaceutical, food, and cosmetic industries. Glutathione is produced industrially by fermentation using Saccharomyces cerevisiae, and supplementation of fermentation with several amino acids can increase intracellular GSH content. More recently, however, focus has been given to protein as a resource for biofuel and fine chemical production. We demonstrate that expression of a protease on the cell surface of S. cerevisiae enables the direct use of keratin and soy protein as a source of amino acids and that these substrates enhanced intracellular GSH content. Furthermore, fermentation using soy protein also enhanced cell concentration. GSH fermentation from keratin and to a greater extent from soy protein using protease-displaying yeast yielded greater GSH productivity compared to GSH fermentation with amino acid supplementation. This protease-displaying yeast is potentially applicable to a variety of processes for the bio-production of value-added chemicals from proteinaceous biomass resources.
Starting Page	1495
Ending Page	1502
Page Count	8
File Format	PDF
ISSN	01757598
Journal	Applied Microbiology and Biotechnology
Volume Number	93
Issue Number	4
e-ISSN	14320614
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-11-11
Publisher Place	Berlin, Heidelberg
Access Restriction	Subscribed
Subject Keyword	Glutathione Yeast Protease Proteinaceous biomass Biorefinery Microbial Genetics and Genomics Microbiology Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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