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Consistent across-tissue signatures of differential gene expression in Crohn's disease

Content Provider	Springer Nature Link
Author	Hughes, Austin L.
Copyright Year	2005
Abstract	An approach based on analysis of variance was applied to raw expression data on 44,760 transcripts in order to identify those with significant differential expression across ileum and colon in Crohn's disease (CD) and ulcerative colitis (UC). The design treated tissue as a block effect, thereby removing this effect statistically and increasing the power to test for effects of disease states (control, CD, and UC). A significant F-statistic for the disease effect was not correlated with the ratios CD/control or UC/control, evidently because many transcripts with high-expression ratios to the control showed inconsistent patterns across tissues. Of 1,053 transcripts showing a significant effect of disease state at the 1% level by the bootstrap test, 508 showed significant difference at the 1% level in a post hoc test for difference between the mean scores for CD and control. These included a number of genes relevant to the mechanism of pathogenesis of CD and a number of genes mapping to genomic regions that have previously shown linkage to CD in association studies.
Starting Page	709
Ending Page	716
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	57
Issue Number	10
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-09-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Crohn's disease Gene expression Inflammatory bowel disease Microarray data Cell Biology Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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