NDLI: Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study

Content Provider	Springer Nature Link
Author	White, Marquitta J. Risse Adams, O. Goddard, P. Contreras, M. G. Adams, J. Hu, D. Eng, C. Oh, S. S. Davis, A. Meade, K. Brigi Buenaventura, E. Leir, M. A. Bibbins Domingo, K. Pi Yanes, M. Burchard, E. G.
Copyright Year	2016
Abstract	Asthma, an inflammatory disorder of the airways, is the most common chronic disease of children worldwide. There are significant racial/ethnic disparities in asthma prevalence, morbidity, and mortality among US children. This trend is mirrored in obesity, which may share genetic and environmental risk factors with asthma. The majority of asthma biomedical research has been performed in populations of European decent. We sought to identify genetic risk factors for asthma in African American children. We also assessed the generalizability of genetic variants associated with asthma in European and Asian populations to African American children. Our study population consisted of 1227 (812 asthma cases, 415 controls) African American children with genome-wide single nucleotide polymorphism (SNP) data. Logistic regression was used to identify associations between SNP genotype and asthma status. We identified a novel variant in the PTCHD3 gene that is significantly associated with asthma (rs660498, p = 2.2 × 10−7) independent of obesity status. Approximately 5 % of previously reported asthma genetic associations identified in European populations replicated in African Americans. Our identification of novel variants associated with asthma in African American children, coupled with our inability to replicate the majority of findings reported in European Americans, underscores the necessity for including diverse populations in biomedical studies of asthma.
Starting Page	391
Ending Page	400
Page Count	10
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	68
Issue Number	6-7
e-ISSN	14321211
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-05-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Health disparities Children Asthma Genetics GWAS Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Novel Genetic Risk factors for Asthma in African American Children: Precision Medicine and The SAGE II Study

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