NDLI: Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations

Content Provider	Springer Nature Link
Author	Magalhães, Vanessa Abrantes, Joana Munõz Pajares, Antonio Jesús Esteves, Pedro J.
Copyright Year	2015
Abstract	The European rabbit (Oryctolagus cuniculus) natural populations within the species native region, the Iberian Peninsula, are considered a reservoir of genetic diversity. Indeed, the Iberia was a Pleistocene refuge to the species and currently two subspecies are found in the peninsula (Oryctolagus cuniculus cuniculus and Oryctolagus cuniculus algirus). The genes of the major histocompatibility complex (MHC) have been substantially studied in wild populations due to their exceptional variability, believed to be pathogen driven. They play an important function as part of the adaptive immune system affecting the individual fitness and population viability. In this study, the MHC variability was assessed by analysing the exon 2 of the DQA gene in several European rabbit populations from Portugal, Spain and France and in domestic breeds. Twenty-eight DQA alleles were detected, among which 18 are described for the first time. The Iberian rabbit populations are well differentiated from the French population and domestic breeds. The Iberian populations retained the higher allelic diversity with the domestic breeds harbouring the lowest; in contrast, the DQA nucleotide diversity was higher in the French population. Signatures of positive selection were detected in four codons which are putative peptide-binding sites and have been previously detected in other mammals. The evolutionary relationships showed instances of trans-species polymorphism. Overall, our results suggest that the DQA in European rabbits is evolving under selection and genetic drift
Starting Page	579
Ending Page	590
Page Count	12
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	67
Issue Number	10
e-ISSN	14321211
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-08-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	European rabbit (Oryctolagus cuniculus) MHC-DQA Population genetics Genetic diversity Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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