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Mamu-B genes and their allelic repertoires in different populations of Chinese-origin rhesus macaques

Content Provider	Springer Nature Link
Author	Liu, Yi Li, Aixue Wang, Xin Sui, Lihua Li, Min Zhao, Yanbin Liu, Bing Zeng, Lin Sun, Zhaozeng
Copyright Year	2012
Abstract	Since rhesus monkeys of Chinese origin have gained greater utilization in recent years, it is urgent to investigate the major histocompatibility complex (MHC) immunogenetics of Chinese rhesus macaques. In this study, we identified 81 Mamu-B sequences using complementary DNA cloning and sequencing on a cohort of 58 rhesus monkeys derived from three local populations of China. Twenty of these Mamu-B alleles are novel and four of them represent new lineages. Although more alleles are shared among different populations than Mamu-A locus, the Mamu-B allelic repertoires found in these three populations of Chinese macaques are largely independent, which underscores the MHC polymorphism among different populations of Chinese rhesus macaques. Our results are an important addition to the limited MHC immunogenetic information available for rhesus macaques of Chinese origin.
Starting Page	273
Ending Page	280
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	65
Issue Number	4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-12-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rhesus macaques Mamu-B Polymorphism Splice variant Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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