NDLI: MHC class I allele frequencies in pigtail macaques of diverse origin

Content Provider	Springer Nature Link
Author	Pratt, Bridget F. O’Conr, David H. Lafont, Bernard A. P. Mankowski, Joseph L. Fernandez, Caroline S. Triastuti, Ret Brooks, Andrew G. Kent, Stephen J. Smith, Miranda Z.
Copyright Year	2006
Abstract	Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8+ T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; however, MHC class I alleles have not yet been comprehensively characterized in pigtail macaques. The frequencies of ten previously defined alleles (four Mane-A and six Mane-B) were investigated in detail in 109 pigtail macaques using reference strand-mediated conformational analysis (RSCA). The macaques were derived from three separate breeding colonies in the USA, Indonesia and Australia, and allele frequencies were analysed within and between these groups. Mane-A10, an allele that restricts the immunodominant SIV Gag epitope KP9, was the most common allele, present in 32.1% of the animals overall, with similar frequencies across the three cohorts. Additionally, RSCA identified a new allele (Mane-A17) common to three Indonesian pigtail macaques responding to the same Gag CD8+ T cell epitope. This broad characterization of common MHC class I alleles in more than 100 pigtail macaques further develops this animal model for the study of virus-specific CD8+ T cell responses.
Starting Page	995
Ending Page	1001
Page Count	7
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	12
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-11-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pigtail macaques MHC class I Reference strand-mediated conformational analysis (RSCA) CD8+ T cell Cell Biology Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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