NDLI: CDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells

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CDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells

Content Provider	Springer Nature Link
Author	Nejad, Shirin Bryceson, Yenan Dissen, Erik Sundvold Gjerstad, Vibeke Naper, Christian Rolstad, Bent Spurkland, Anne Vaage, John Torgils
Copyright Year	2004
Abstract	The T-cell-specific adapter protein (TSAd), encoded by the SH2D2A gene, has been implicated in modulation of proximal signaling events as well as in transcriptional regulation in human T cells. We have isolated its rat homologue (rSH2D2A) from an NK cell cDNA library and mapped the corresponding gene to chromosome 2 with a hamster-rat radiation hybrid cell panel. rSH2D2A encodes a 376 amino acid protein (rTSAd) which shows greater homology to mouse than human TSAd. In rats, rTSAd was specifically expressed by NK cells and T cells but not by other leukocytes tested. Similarly, in humans we observed abundant transcripts for TSAd in NK cells and T cells. The data suggest that TSAd may have a regulatory role in cellular activation of T and NK cells.
Starting Page	338
Ending Page	342
Page Count	5
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	56
Issue Number	5
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-08-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Signal transduction Adapter molecules Lymphocytes
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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