NDLI: Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells

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Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells

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Year: 2008 Volume: 181 Issue: 2

Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oliver, Jennifer A. King, Philip D. Saunders, Thomas L. Lapinski, Philip E. Kamen, Lynn A. Hughes, Elizabeth D.
Description	Country affiliation: United States Author Affiliation: Lapinski PE ( Department of Microbiology and Immunology, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.)
Abstract	T cell-specific adapter (TSAd) protein and adapter protein in lymphocytes of unknown function (ALX) are two related Src homology 2 (SH2) domain-containing signaling adapter molecules that have both been shown to regulate TCR signal transduction in T cells. TSAd is required for normal TCR-induced synthesis of IL-2 and other cytokines in T cells and acts at least in part by promoting activation of the LCK protein tyrosine kinase at the outset of the TCR signaling cascade. By contrast, ALX functions as a negative-regulator of TCR-induced IL-2 synthesis through as yet undetermined mechanisms. In this study, we report a novel T cell-expressed adapter protein named SH2D4A that contains an SH2 domain that is highly homologous to the TSAd protein and ALX SH2 domains and that shares other structural features with these adapters. To examine the function of SH2D4A in T cells we produced SH2D4A-deficient mice by homologous recombination in embryonic stem cells. T cell development, homeostasis, proliferation, and function were all found to be normal in these mice. Furthermore, knockdown of SH2D4A expression in human T cells did not impact upon their function. We conclude that in contrast to TSAd and ALX proteins, SH2D4A is dispensable for TCR signal transduction in T cells.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	3
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adaptor Proteins, Signal Transducing Metabolism Intracellular Signaling Peptides And Proteins Genetics Membrane Proteins T-lymphocytes Immunology Chemistry Deficiency Amino Acid Sequence Animals Cell Line Listeriosis Mice Mice, Knockout Molecular Sequence Data Rna, Small Interfering Sequence Alignment Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells1

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Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells

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Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells1

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Genetic Analysis of SH2D4A, a Novel Adapter Protein Related to TSAd and ALX, Reveals a Redundant Function in T cells