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Immunogenetics : Volume 58, Issue 1, February 2006

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VEGF gene variability and type 1 diabetes: evidence for a protective role

Content Provider	Springer Nature Link
Author	Bo, Roberto Scarlato, Marina Ghezzi, Serena Maestroni, Anna Sjölind, Lisa Forsblom, Carol Wessman, Maija Groop, Per Henrik Comi, Giacomo Pietro Bresolin, Nereo Luzi, Livio Zerbini, Gianpaolo
Copyright Year	2006
Abstract	Vascular endothelial growth factor (VEGF) is a multifunctional cytokine originally described as an angiogenic factor. A number of reports have recently demonstrated that VEGF increases pancreatic islet survival after islet transplantation by stimulating angiogenesis and improving islet revascularization. Whether VEGF can protect from the autoimmune destruction of insulin-producing beta-cells that characterizes the development of type 1 diabetes is presently unknown. To clarify this issue, we studied the association of three polymorphisms of the promoter region of VEGF with type 1 diabetes in the Italian and the Finnish populations. The polymorphisms considered [C(-2578)A, G(-1190)A, and G(-1154)A] are known to modulate in vitro and in vivo VEGF expression. We found that VEGF promoter genotypes are associated with type 1 diabetes in both populations, but with different combinations. In Italian individuals, the -2578AA and -1190AA genotypes are associated with type 1 diabetes and accelerate its onset, while in Finnish individuals, -1154GG and -1190GG protect from type 1 diabetes and delay its onset. In conclusion, because the expected functional consequence of both genotype combinations is a reduced VEGF expression in diabetic patients, we propose a protective role of VEGF in the development of type 1 diabetes.
Starting Page	107
Ending Page	112
Page Count	6
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	2-3
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-03-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Type 1 diabetes Cytokines Tolerance
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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