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Immunogenetics : Volume 58, Issue 1, February 2006

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Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating γδ T cells

Content Provider	Springer Nature Link
Author	Herzig, Carolyn Blumerman, Seth Lefranc, Marie Paule Baldwin, Cynthia
Copyright Year	2006
Abstract	Studies here describe expression and sequence of several new bovine T cell receptor gamma (TRG) genes to yield a total of 11 TRG variable (TRGV) genes (in eight subgroups) and six TRG constant (TRGC) genes. Publicly available genomic sequences were annotated to show their placement. Homologous TRG genes in cattle and sheep were assigned, using four accepted criteria. New genes described here include the bovine TRGC6, TRGV2, and TRGV4, homologues of ovine TRGC4, TRGV2, and TRGV4, respectively. The bovine Vγ7 and BTGV1 clones (previously TRGV4 and TRGV2, respectively) were reassigned to new subgroups TRGV7 and TRGV8, respectively, with approval by the IMGT Nomenclature Committee. Three TRGV subgroups (TRGV5, TRGV6, and TRGV8) were further designated as TRGV5-1 and TRGV5-2, TRGV6-1 and TRGV6-2, and TRGV8-1 and TRGV8-2 because each subgroup is comprised of two mapped genes. The complete sequence of bovine TRGC5 is also reported, for which a limited number of nucleotides was previously available, and shown to be most closely related to ovine TRGC5. Analysis of circulating γδ T cells revealed that rearrangement of TRGV genes with TRGC genes is largely dictated by their proximity within one of the six genomic V-J-C cassettes, with all TRG genes expressed by bovine peripheral blood γδ T cells. Cattle are useful models for γδ T cell biology because they have γδ T cells that respond to isopentenylpyrophosphate (IPP) antigens, while mice do not, and some bovine TRGV genes cluster closely with human genes.
Starting Page	138
Ending Page	151
Page Count	14
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	2-3
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-03-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	γδ T cells γδ T cell receptor genes TRGC TRGV Ruminant
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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