NDLI: Molecular polymorphism of O alleles in five populations of different ethnic origins

Content Provider	Springer Nature Link
Author	Roubinet, Francis Kermarrec, Nathalie Despiau, Stéphanie Apoil, Pol Andre Dugoujon, Jean Michel Blancher, Antoine
Copyright Year	2001
Abstract	Sequences of exons 6 and 7 of the O allele of the ABO gene were studied in 317 individuals of the O phenotype from five different ethnic groups (Basques, Berbers, Akans from the Ivory Coast, and Amerindians: Cayapas from Ecuador and Aymaras from Bolivia). Twenty-one O alleles were characterized, among which 9 differed from all O alleles reported to date. The nine alleles differed from either the O01 allele (four out of nine) or O02 allele (five out of nine) by one to three point mutations. The number of different O alleles in population samples varied greatly: the highest number (13) was observed in Akans, and the lowest (5) in Amerindians. Some rare alleles previously reported by others at low frequencies were found with high frequencies in the Akans. The results also revealed a decreasing frequency of O v7 alleles from south to north (Akans, Berbers, Basques). Berbers and Basques share two rare alleles, O v6 and O03, which were not encountered in the other populations studied here.
Starting Page	95
Ending Page	104
Page Count	10
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	53
Issue Number	2
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-03-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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