NDLI: Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus)

Content Provider	Springer Nature Link
Author	Lau, Quintin Jobbins, Sarah E. Belov, Katherine Higgins, Damien P.
Copyright Year	2012
Abstract	Major histocompatibility complex (MHC) class II molecules have an integral role in the adaptive immune response, as they bind and present antigenic peptides to T helper lymphocytes. In this study of koalas, species-specific primers were designed to amplify exon 2 of the MHC class II DA and DB genes, which contain much of the peptide-binding regions of the α and β chains. A total of two DA α1 domain variants and eight DA β1 (DAB), three DB α1 and five DB β1 variants were amplified from 20 koalas from two free-living populations from South East Queensland and the Port Macquarie region in northern New South Wales. We detected greater variation in the β1 than in the α1 domains as well as evidence of positive selection in DAB. The present study provides a springboard to future investigation of the role of MHC in disease susceptibility in koalas.
Starting Page	37
Ending Page	46
Page Count	10
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	65
Issue Number	1
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-10-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Koala Phascolarctos cinereus MHC class II Marsupial Diversity Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus)